Hypomethylating Agent Azacitidine Is Effective in Treating Brain Metastasis Triple-Negative Breast Cancer Through Regulation of DNA Methylation of Keratin 18 Gene

Breast cancer patients presenting with symptomatic brain metastases have poor prognosis, and current chemotherapeutic agents are largely ineffective. In this study, we evaluated the hypomethylating agent azacitidine (AZA) for its potential as a novel therapeutic in preclinical models of brain metast...

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Detalles Bibliográficos
Autores principales: Butler, Christopher, Sprowls, Samuel, Szalai, Gabor, Arsiwala, Tasneem, Saralkar, Pushkar, Straight, Benjamin, Hatcher, Shea, Tyree, Evan, Yost, Michael, Kohler, William J., Wolff, Benjamin, Putnam, Emily, Lockman, Paul, Liu, Tuoen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Review article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225776/
https://www.ncbi.nlm.nih.gov/pubmed/32408199
http://dx.doi.org/10.1016/j.tranon.2020.100775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225776/
https://www.ncbi.nlm.nih.gov/pubmed/32408199
http://dx.doi.org/10.1016/j.tranon.2020.100775

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