TNFa and IL2 Encoding Oncolytic Adenovirus Activates Pathogen and Danger-Associated Immunological Signaling

In order to break tumor resistance towards traditional treatments, we investigate the response of tumor and immune cells to a novel, cytokine-armed oncolytic adenovirus: Ad5/3-d24-E2F-hTNFa-IRES-hIL2 (also known as TILT-123 and OAd.TNFa-IL2). There are several pattern recognition receptors (PRR) tha...

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Detalles Bibliográficos
Autores principales: Heiniö, Camilla, Havunen, Riikka, Santos, Joao, de Lint, Klaas, Cervera-Carrascon, Victor, Kanerva, Anna, Hemminki, Akseli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225950/
https://www.ncbi.nlm.nih.gov/pubmed/32225009
http://dx.doi.org/10.3390/cells9040798

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225950/
https://www.ncbi.nlm.nih.gov/pubmed/32225009
http://dx.doi.org/10.3390/cells9040798

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