Cargando…

Activins as Dual Specificity TGF-β Family Molecules: SMAD-Activation via Activin- and BMP-Type 1 Receptors

Activins belong to the transforming growth factor (TGF)-β family of multifunctional cytokines and signal via the activin receptors ALK4 or ALK7 to activate the SMAD2/3 pathway. In some cases, activins also signal via the bone morphogenetic protein (BMP) receptor ALK2, causing activation of the SMAD1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Olsen, Oddrun Elise, Hella, Hanne, Elsaadi, Samah, Jacobi, Carsten, Martinez-Hackert, Erik, Holien, Toril
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225989/ https://www.ncbi.nlm.nih.gov/pubmed/32235336 http://dx.doi.org/10.3390/biom10040519

Ejemplares similares

Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B
por: Olsen, Oddrun Elise, et al.
Publicado: (2015)

TGF-β contamination of purified recombinant GDF15
por: Olsen, Oddrun Elise, et al.
Publicado: (2017)

An autocrine ActivinB mechanism drives TGFβ/Activin signaling in Group 3 medulloblastoma
por: Morabito, Morgane, et al.
Publicado: (2019)

Activin A forms a non-signaling complex with ACVR1 and type II Activin/BMP receptors via its finger 2 tip loop
por: Aykul, Senem, et al.
Publicado: (2020)

High concentrations of soluble endoglin can inhibit BMP9 signaling in non-endothelial cells
por: Andersson-Rusch, Clara, et al.
Publicado: (2023)

Activin E is a TGFβ ligand that signals specifically through activin receptor-like kinase 7
por: Vestal, Kylie A, et al.
Publicado: (2023)

R-Smad Competition Controls Activin Receptor Output in Drosophila
por: Peterson, Aidan J., et al.
Publicado: (2012)

Type II BMP and activin receptors BMPR2 and ACVR2A share a conserved mode of growth factor recognition
por: Chu, Kit-Yee, et al.
Publicado: (2022)

Activin A regulates activation of mouse neutrophils by Smad3 signalling
por: Qi, Yan, et al.
Publicado: (2017)

Competition between type I activin and BMP receptors for binding to ACVR2A regulates signaling to distinct Smad pathways
por: Szilágyi, Szabina Szófia, et al.
Publicado: (2022)

Effects of Activin and TGFβ on p21 in Colon Cancer
por: Bauer, Jessica, et al.
Publicado: (2012)

Different Immunoregulation Roles of Activin A Compared With TGF-β
por: Li, Fanglin, et al.
Publicado: (2022)

Activin eases asthma
por: Leslie, Mitch
Publicado: (2009)

Dual Roles of the Activin Signaling Pathway in Pancreatic Cancer
por: Qiu, Wanglong, et al.
Publicado: (2021)

BMP and Activin Membrane Bound Inhibitor Regulates the Extracellular Matrix in the Trabecular Meshwork
por: Hernandez, Humberto, et al.
Publicado: (2018)

Activin A Stimulates Aromatase via the ALK4-Smad Pathway in Endometriosis
por: Zheng, Juan, et al.
Publicado: (2016)

Dual Inhibition of Activin/Nodal/TGF-β and BMP Signaling Pathways by SB431542 and Dorsomorphin Induces Neuronal Differentiation of Human Adipose Derived Stem Cells
por: Madhu, Vedavathi, et al.
Publicado: (2016)

Intertwining of Activin A and TGFβ Signaling: Dual Roles in Cancer Progression and Cancer Cell Invasion
por: Loomans, Holli A., et al.
Publicado: (2014)

TGFβ and activin A control regulatory T cells in irradiated tumors
por: Vanpouille-Box, Claire, et al.
Publicado: (2015)

Activin A backs-up TGF-ß to promote regulatory T cells
por: De Martino, Mara, et al.
Publicado: (2021)

The orphan ligand, activin C, signals through activin receptor-like kinase 7
por: Goebel, Erich J, et al.
Publicado: (2022)

Human and mouse activin genes: Divergent expression of activin A protein variants and identification of a novel heparan sulfate-binding domain in activin B
por: Billings, Paul C., et al.
Publicado: (2020)

Palbociclib enhances activin‐SMAD‐induced cytostasis in estrogen receptor‐positive breast cancer
por: Harada, Mayumi, et al.
Publicado: (2018)

Activin A Levels Are Associated With Abnormal Glucose Regulation in Patients With Myocardial Infarction: Potential Counteracting Effects of Activin A on Inflammation
por: Andersen, Geir Ø., et al.
Publicado: (2011)

Xnrs and Activin Regulate Distinct Genes during Xenopus Development: Activin Regulates Cell Division
por: Ramis, Joana M., et al.
Publicado: (2007)

Activin B and Activin C Have Opposing Effects on Prostate Cancer Progression and Cell Growth
por: Reader, Karen L., et al.
Publicado: (2022)

Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer
por: Bauer, Jessica, et al.
Publicado: (2015)

Efficient retina formation requires suppression of both Activin and BMP signaling pathways in pluripotent cells
por: Wong, Kimberly A., et al.
Publicado: (2015)

Activin Is Superior to BMP7 for Efficient Maintenance of Human iPSC-Derived Nephron Progenitors
por: Tanigawa, Shunsuke, et al.
Publicado: (2019)

Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues
por: Schaik, R H N van, et al.
Publicado: (2000)

Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects
Publicado: (1995)

Activin Biology After Lung Transplantation
por: Westall, Glen P., et al.
Publicado: (2017)

Structure and activation of pro-activin A
por: Wang, Xuelu, et al.
Publicado: (2016)

Activin, neutrophils, and inflammation: just coincidence?
por: Sideras, Paschalis, et al.
Publicado: (2013)

An Activin Receptor IA/Activin-Like Kinase-2 (R206H) Mutation in Fibrodysplasia Ossificans Progressiva
por: Herrera-Esparza, Rafael, et al.
Publicado: (2013)

The Activin Receptor, Activin-Like Kinase 4, Mediates Toxoplasma Gondii Activation of Hypoxia Inducible Factor-1
por: Lis, Agnieszka, et al.
Publicado: (2019)

Comparable Generation of Activin-Induced Definitive Endoderm via Additive Wnt or BMP Signaling in Absence of Serum
por: Teo, Adrian Kee Keong, et al.
Publicado: (2014)

Activin-A and Bmp4 Levels Modulate Cell Type Specification during CHIR-Induced Cardiomyogenesis
por: Kim, Min-Su, et al.
Publicado: (2015)

Activin and BMP Signaling Activity Affects Different Aspects of Host Anti-Nematode Immunity in Drosophila melanogaster
por: Ozakman, Yaprak, et al.
Publicado: (2021)

Expression and Function of BMP and Activin Membrane-Bound Inhibitor (BAMBI) in Chronic Liver Diseases and Hepatocellular Carcinoma
por: Weber, Florian, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_gebledtivi2qq8h5udik3jfle3