ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis

The role of Situin 1 (SIRT1) in tumorigenesis is still controversial due to its wide range of substrates, including both oncoproteins and tumor suppressors. A recent study has demonstrated that SIRT1 interferes in the Kirsten rat sarcoma viral oncogene homolog (KRAS)-driven activation of the Raf-mit...

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Detalles Bibliográficos
Autores principales: Kwon, Ok-Seon, Lee, Haeseung, Kim, Yun-Jeong, Cha, Hyuk-Jin, Song, Na-Young, Lee, Mi-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225992/
https://www.ncbi.nlm.nih.gov/pubmed/32276460
http://dx.doi.org/10.3390/cancers12040909

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225992/
https://www.ncbi.nlm.nih.gov/pubmed/32276460
http://dx.doi.org/10.3390/cancers12040909

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