BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer

The aberrant hypermethylation of BRCA1 promoter CpG islands induces the decreased expression of BRCA1 (Breast Cancer 1) protein. It can be detected in sporadic breast cancer without BRCA1 pathogenic variants, particularly in triple-negative breast cancers (TNBC). We investigated BRCA1 hypermethylati...

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Detalles Bibliográficos
Autores principales: Jacot, William, Lopez-Crapez, Evelyne, Mollevi, Caroline, Boissière-Michot, Florence, Simony-Lafontaine, Joelle, Ho-Pun-Cheung, Alexandre, Chartron, Elodie, Theillet, Charles, Lemoine, Antoinette, Saffroy, Raphael, Lamy, Pierre-Jean, Guiu, Séverine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225997/
https://www.ncbi.nlm.nih.gov/pubmed/32235500
http://dx.doi.org/10.3390/cancers12040828

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225997/
https://www.ncbi.nlm.nih.gov/pubmed/32235500
http://dx.doi.org/10.3390/cancers12040828

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