Cargando…

Structure–Activity Relationships and Molecular Docking Analysis of Mcl-1 Targeting Renieramycin T Analogues in Patient-derived Lung Cancer Cells

Myeloid cell leukemia 1 (Mcl-1) and B-cell lymphoma 2 (Bcl-2) proteins are promising targets for cancer therapy. Here, we investigated the structure–activity relationships (SARs) and performed molecular docking analysis of renieramycin T (RT) and its analogues and identified the critical functional...

Descripción completa

Detalles Bibliográficos
Autores principales:	Petsri, Korrakod, Yokoya, Masashi, Tungsukruthai, Sucharat, Rungrotmongkol, Thanyada, Nutho, Bodee, Vinayanuwattikun, Chanida, Saito, Naoki, Takehiro, Matsubara, Sato, Ryo, Chanvorachote, Pithi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226000/ https://www.ncbi.nlm.nih.gov/pubmed/32260280 http://dx.doi.org/10.3390/cancers12040875

Ejemplares similares

Titania Nanosheet Generates Peroxynitrite-Dependent S-Nitrosylation and Enhances p53 Function in Lung Cancer Cells
por: Soonnarong, Rapeepun, et al.
Publicado: (2021)

Renieramycin T Induces Lung Cancer Cell Apoptosis by Targeting Mcl-1 Degradation: A New Insight in the Mechanism of Action
por: Petsri, Korrakod, et al.
Publicado: (2019)

Light-Mediated Transformation of Renieramycins and Semisynthesis of 4′-Pyridinecarbonyl-Substituted Renieramycin-Type Derivatives as Potential Cytotoxic Agents against Non-Small-Cell Lung Cancer Cells
por: Sinsook, Suwimon, et al.
Publicado: (2023)

Novel Synthetic Derivative of Renieramycin T Right-Half Analog Induces Apoptosis and Inhibits Cancer Stem Cells via Targeting the Akt Signal in Lung Cancer Cells
por: Petsri, Korrakod, et al.
Publicado: (2023)

Pongol Methyl Ether Inhibits Akt and Suppresses Cancer Stem Cell Phenotypes in Lung Cancer Cells
por: Silapech, Arnon, et al.
Publicado: (2021)

Structural modification of resveratrol analogue exhibits anticancer activity against lung cancer stem cells via suppression of Akt signaling pathway
por: Thongsom, Sunisa, et al.
Publicado: (2023)

Targeting AKT/mTOR and Bcl-2 for Autophagic and Apoptosis Cell Death in Lung Cancer: Novel Activity of a Polyphenol Compound
por: Tungsukruthai, Sucharat, et al.
Publicado: (2021)

Cycloartocarpin Inhibits Migration through the Suppression of Epithelial-to-Mesenchymal Transition and FAK/AKT Signaling in Non-Small-Cell Lung Cancer Cells
por: Tungsukruthai, Sucharat, et al.
Publicado: (2022)

Tubulin acetylation enhances lung cancer resistance to paclitaxel-induced cell death through Mcl-1 stabilization
por: Wattanathamsan, Onsurang, et al.
Publicado: (2021)

Akt/mTOR Targeting Activity of Resveratrol Derivatives in Non-Small Lung Cancer
por: Innets, Bhurichaya, et al.
Publicado: (2022)

Discovery of C-12 dithiocarbamate andrographolide analogues as inhibitors of SARS-CoV-2 main protease: In vitro and in silico studies
por: Nutho, Bodee, et al.
Publicado: (2022)

Chemistry of Renieramycins. Part 14: Total Synthesis of Renieramycin I and Practical Synthesis of Cribrostatin 4 (Renieramycin H)
por: Yokoya, Masashi, et al.
Publicado: (2015)

Asymmetric Synthesis and Cytotoxicity Evaluation of Right-Half Models of Antitumor Renieramycin Marine Natural Products
por: Matsubara, Takehiro, et al.
Publicado: (2018)

Delivery of Alpha-Mangostin Using Cyclodextrins through a Biological Membrane: Molecular Dynamics Simulation
por: Hotarat, Wiparat, et al.
Publicado: (2020)

Chemistry of Renieramycins. Part 19: Semi-Syntheses of 22-O-Amino Ester and Hydroquinone 5-O-Amino Ester Derivatives of Renieramycin M and Their Cytotoxicity against Non-Small-Cell Lung Cancer Cell Lines
por: Chamni, Supakarn, et al.
Publicado: (2020)

Caffeine Induces G0/G1 Cell Cycle Arrest and Inhibits Migration through Integrin αv, β3, and FAK/Akt/c-Myc Signaling Pathway
por: Meisaprow, Pichitchai, et al.
Publicado: (2021)

5-O-Acetyl-Renieramycin T from Blue Sponge Xestospongia sp. Induces Lung Cancer Stem Cell Apoptosis
por: Chantarawong, Wipa, et al.
Publicado: (2019)

Binding mode and free energy prediction of fisetin/β-cyclodextrin inclusion complexes
por: Nutho, Bodee, et al.
Publicado: (2014)

Novel mechanism of napabucasin, a naturally derived furanonaphthoquinone: apoptosis and autophagy induction in lung cancer cells through direct targeting on Akt/mTOR proteins
por: Petsri, Korrakod, et al.
Publicado: (2022)

Structural Basis of Specific Glucoimidazole and Mannoimidazole Binding by Os3BGlu7
por: Nutho, Bodee, et al.
Publicado: (2020)

Hydroquinone 5-O-Cinnamoyl Ester of Renieramycin M Suppresses Lung Cancer Stem Cells by Targeting Akt and Destabilizes c-Myc
por: Hongwiangchan, Nattamon, et al.
Publicado: (2021)

In Vitro and In Silico Study on the Molecular Encapsulation of α-Tocopherol in a Large-Ring Cyclodextrin
por: Sangkhawasi, Mattanun, et al.
Publicado: (2023)

N,Nʹ-Diarylurea Derivatives (CTPPU) Inhibited NSCLC Cell Growth and Induced Cell Cycle Arrest through Akt/GSK-3β/c-Myc Signaling Pathway
por: Thongsom, Sunisa, et al.
Publicado: (2023)

Artocarpin Targets Focal Adhesion Kinase-Dependent Epithelial to Mesenchymal Transition and Suppresses Migratory-Associated Integrins in Lung Cancer Cells
por: Nonpanya, Nongyao, et al.
Publicado: (2021)

Development of a human antibody fragment directed against the alpha folate receptor as a promising molecule for targeted application
por: Parakasikron, Nattihda, et al.
Publicado: (2021)

A novel TRPM7/O-GlcNAc axis mediates tumour cell motility and metastasis by stabilising c-Myc and caveolin-1 in lung carcinoma
por: Luanpitpong, Sudjit, et al.
Publicado: (2020)

Inhibition of histone deacetylase 6 destabilizes ERK phosphorylation and suppresses cancer proliferation via modulation of the tubulin acetylation-GRP78 interaction
por: Wattanathamsan, Onsurang, et al.
Publicado: (2023)

5-O-(N-Boc-l-Alanine)-Renieramycin T Induces Cancer Stem Cell Apoptosis via Targeting Akt Signaling
por: Suksamai, Darinthip, et al.
Publicado: (2022)

GRP78/BiP determines senescence evasion cell fate after cisplatin-based chemotherapy
por: Ei, Zin Zin, et al.
Publicado: (2021)

Aspiletrein A Induces Apoptosis Cell Death via Increasing Reactive Oxygen Species Generation and AMPK Activation in Non-Small-Cell Lung Cancer Cells
por: Witayateeraporn, Wasita, et al.
Publicado: (2022)

Microarray-Based Transcriptional Profiling of Renieramycin M and Jorunnamycin C, Isolated from Thai Marine Organisms
por: Charupant, Kornvika, et al.
Publicado: (2009)

Structural Dynamics of the Precatalytic State of Human Cytochrome c upon T28C, G34C, and A50C Mutations: A Molecular Dynamics Simulation Perspective
por: Nutho, Bodee, et al.
Publicado: (2023)

Construction of the Pentacyclic Core and Formal Total Synthesis of (rac)‐Renieramycin T
por: Kimura, Shinya, et al.
Publicado: (2018)

Construction of the Pentacyclic Core and Formal Total Synthesis of (rac)‐Renieramycin T
por: Kimura, Shinya, et al.
Publicado: (2018)

The Effects of 12-Week Traditional Thai Exercise (Ruesi Dadton) on Glycemic Control and Inflammatory Markers in Prediabetes: A Randomized Controlled Trial
por: Sawangwong, Pornchai, et al.
Publicado: (2023)

Fisetin glycosides synthesized by cyclodextrin glycosyltransferase from Paenibacillus sp. RB01: characterization, molecular docking, and antioxidant activity
por: Lorthongpanich, Nattawadee, et al.
Publicado: (2022)

Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp.
por: Nakao, Yoichi, et al.
Publicado: (2004)

Synergistic Cytotoxicity of Renieramycin M and Doxorubicin in MCF-7 Breast Cancer Cells
por: Tun, Jortan O., et al.
Publicado: (2019)

Quinoxalinones as A Novel Inhibitor Scaffold for EGFR (L858R/T790M/C797S) Tyrosine Kinase: Molecular Docking, Biological Evaluations, and Computational Insights
por: Suriya, Utid, et al.
Publicado: (2022)

Gigantol Suppresses Cancer Stem Cell-Like Phenotypes in Lung Cancer Cells
por: Bhummaphan, Narumol, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_55bia6j9vc830vvfljk231dq1u