Effect of Transgene Location, Transcriptional Control Elements and Transgene Features in Armed Oncolytic Adenoviruses

Clinical results with oncolytic adenoviruses (OAds) used as antitumor monotherapies show limited efficacy. To increase OAd potency, transgenes have been inserted into their genome, a strategy known as “arming OAds”. Here, we review different parameters that affect the outcome of armed OAds. Recombin...

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Detalles Bibliográficos
Autores principales: Farrera-Sal, Martí, Fillat, Cristina, Alemany, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226017/
https://www.ncbi.nlm.nih.gov/pubmed/32340119
http://dx.doi.org/10.3390/cancers12041034

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226017/
https://www.ncbi.nlm.nih.gov/pubmed/32340119
http://dx.doi.org/10.3390/cancers12041034

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