Cargando…

Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer

Colorectal cancer’s (CRC) ability to invade local tissues and lymph nodes and generate distant metastases is the key for TNM classification. Aspartate-β-hydroxylase (ASPH), a transmembrane protein that catalyzes Notch receptors and ligand activation, is involved in tumor invasion. Because Notch is i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Benelli, Roberto, Costa, Delfina, Mastracci, Luca, Grillo, Federica, Olsen, Mark Jon, Barboro, Paola, Poggi, Alessandro, Ferrari, Nicoletta
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226058/ https://www.ncbi.nlm.nih.gov/pubmed/32295249 http://dx.doi.org/10.3390/cancers12040971

Ejemplares similares

Erratum: Benelli, R., et al. Aspartate-β-Hydroxylase: A Promising Target to Limit the Local Invasiveness of Colorectal Cancer. Cancers 2020, 12, 971
por: Benelli, Roberto, et al.
Publicado: (2020)

Multifocal Signal Modulation Therapy by Celecoxib: A Strategy for Managing Castration-Resistant Prostate Cancer
por: Benelli, Roberto, et al.
Publicado: (2019)

SB202190 Predicts BRAF-Activating Mutations in Primary Colorectal Cancer Organoids via Erk1-2 Modulation
por: Costa, Delfina, et al.
Publicado: (2023)

Evaluation of Glycosylated PTGS2 in Colorectal Cancer for NSAIDS-Based Adjuvant Therapy
por: Venè, Roberta, et al.
Publicado: (2020)

Targeting the Epidermal Growth Factor Receptor Can Counteract the Inhibition of Natural Killer Cell Function Exerted by Colorectal Tumor-Associated Fibroblasts
por: Costa, Delfina, et al.
Publicado: (2018)

Aspartate β-hydroxylase as a target for cancer therapy
por: Kanwal, Madiha, et al.
Publicado: (2020)

Human Gut-Associated Natural Killer Cells in Health and Disease
por: Poggi, Alessandro, et al.
Publicado: (2019)

Diverse molecular functions of aspartate β-hydroxylase in cancer
por: Zheng, Wenqian, et al.
Publicado: (2020)

Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype
por: Dong, Xiaoqun, et al.
Publicado: (2014)

Aspartate-β-hydroxylase (ASPH): A potential therapeutic target in human malignant gliomas
por: Sturla, Lisa-Marie, et al.
Publicado: (2016)

Correction: Aspartate β-hydroxylase expression promotes a malignant pancreatic cellular phenotype
por: Dong, Xiaoqun, et al.
Publicado: (2019)

Androgen Receptor Activity Is Affected by Both Nuclear Matrix Localization and the Phosphorylation Status of the Heterogeneous Nuclear Ribonucleoprotein K in Anti-Androgen-Treated LNCaP Cells
por: Barboro, Paola, et al.
Publicado: (2013)

Targeting of colorectal cancer organoids with zoledronic acid conjugated to the anti-EGFR antibody cetuximab
por: Benelli, Roberto, et al.
Publicado: (2022)

Aspartate β-hydroxylase disrupts mitochondrial DNA stability and function in hepatocellular carcinoma
por: Tang, C, et al.
Publicado: (2017)

Gut inflammation and tumorigenesis: every site has a different tale to tell
por: Vanoli, Alessandro, et al.
Publicado: (2023)

Characterization of the Relationship Between the Expression of Aspartate β-Hydroxylase and the Pathological Characteristics of Breast Cancer
por: Zhang, Yanan, et al.
Publicado: (2020)

Aspartate β-Hydroxylase Serves as a Prognostic Biomarker for Neoadjuvant Chemotherapy in Gastric Cancer
por: Gan, Xuejun, et al.
Publicado: (2023)

Colorectal adenosquamous carcinoma: genomic profiling of a rare histotype of colorectal cancer
por: Angerilli, Valentina, et al.
Publicado: (2023)

Priming of Colorectal Tumor-Associated Fibroblasts with Zoledronic Acid Conjugated to the Anti-Epidermal Growth Factor Receptor Antibody Cetuximab Elicits Anti-Tumor Vδ2 T Lymphocytes
por: Fernandez, Jordi Leonardo Castrillo, et al.
Publicado: (2023)

Synthesis of Novel Pyridine‐Carboxylates as Small‐Molecule Inhibitors of Human Aspartate/Asparagine‐β‐Hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Novel Approach to Overcome Defects of Cell-SELEX in Developing Aptamers against Aspartate β-Hydroxylase
por: Bakhtiari, Hadi, et al.
Publicado: (2021)

Synthesis of 2-oxoglutarate derivatives and their evaluation as cosubstrates and inhibitors of human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Prenatal dexamethasone treatment for classic 21-hydroxylase deficiency in Europe
por: Nowotny, Hanna, et al.
Publicado: (2022)

Endocrine sensitivity of estrogen receptor‐positive breast cancer is negatively correlated with aspartate‐β‐hydroxylase expression
por: Shimoda, Masafumi, et al.
Publicado: (2017)

Construction and Characterization of Adenovirus Vectors Encoding Aspartate-β-Hydroxylase to Preliminary Application in Immunotherapy of Hepatocellular Carcinoma
por: Zhou, Yujiao, et al.
Publicado: (2018)

Aspartate β-hydroxylase promotes pancreatic ductal adenocarcinoma metastasis through activation of SRC signaling pathway
por: Ogawa, Kosuke, et al.
Publicado: (2019)

Aspartate β-Hydroxylase (ASPH) Expression in Acute Myeloid Leukemia: A Potential Novel Therapeutic Target
por: Holtzman, Noa G., et al.
Publicado: (2021)

Morphology and Molecular Features of Rare Colorectal Carcinoma Histotypes
por: Remo, Andrea, et al.
Publicado: (2019)

A Rare Novel Deletion of the Tyrosine Hydroxylase Gene in Parkinson Disease
por: Bademci, Güney, et al.
Publicado: (2010)

Small-molecule active pharmaceutical ingredients of approved cancer therapeutics inhibit human aspartate/asparagine-β-hydroxylase
por: Brewitz, Lennart, et al.
Publicado: (2020)

Kinetic parameters of human aspartate/asparagine–β-hydroxylase suggest that it has a possible function in oxygen sensing
por: Brewitz, Lennart, et al.
Publicado: (2020)

Aspartate/asparagine-β-hydroxylase: a high-throughput mass spectrometric assay for discovery of small molecule inhibitors
por: Brewitz, Lennart, et al.
Publicado: (2020)

Aspartate is an endogenous metabolic limitation for tumour growth
por: Sullivan, Lucas B., et al.
Publicado: (2018)

Extension of Collagen Deposition in COVID-19 Post Mortem Lung Samples and Computed Tomography Analysis Findings
por: Ball, Lorenzo, et al.
Publicado: (2021)

Application of Aspartic Acid Racemization for Age Estimation in a Spanish Sample
por: C. Zapico, Sara, et al.
Publicado: (2022)

Lung fibrosis: an undervalued finding in COVID-19 pathological series
por: Grillo, Federica, et al.
Publicado: (2021)

HLA-G as a prognostic marker in stage II/III colorectal cancer: not quite there yet
por: Gambella, Alessandro, et al.
Publicado: (2022)

SEPARATION OF MITOCHONDRIAL MEMBRANES OF NEUROSPORA CRASSA : I. Localization of L-Kynurenine-3-Hydroxylase
por: Cassady, William E., et al.
Publicado: (1971)

Three-Dimensional Culture Models to Study Innate Anti-Tumor Immune Response: Advantages and Disadvantages
por: Poggi, Alessandro, et al.
Publicado: (2021)

Aspartate beta-hydroxylase domain containing 1 as a prognostic marker associated with immune infiltration in skin cutaneous melanoma
por: Sun, Shiquan, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cb7t538dgcvst1l8a2c17qh0q3