Combining Virtual Screening Protocol and In Vitro Evaluation towards the Discovery of BACE1 Inhibitors

The treatment options for a patient diagnosed with Alzheimer’s disease (AD) are currently limited. The cerebral accumulation of amyloid-β (Aβ) is a critical molecular event in the pathogenesis of AD. When the amyloidogenic β-secretase (BACE1) is inhibited, the production of Aβ peptide is reduced. He...

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Detalles Bibliográficos
Autores principales: Coimbra, Judite R. M., Baptista, Salete J., Dinis, Teresa C. P., Silva, Maria M. C., Moreira, Paula I., Santos, Armanda E., Salvador, Jorge A. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226079/
https://www.ncbi.nlm.nih.gov/pubmed/32244832
http://dx.doi.org/10.3390/biom10040535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226079/
https://www.ncbi.nlm.nih.gov/pubmed/32244832
http://dx.doi.org/10.3390/biom10040535

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