Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility

Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11; 22) (q24; q12). The resulting fusion gene, EWSR1-FLI1, is toxic or unstable in most primary tissues. Consequently, attempts to model Ewing sarcomagenesis have pr...

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Detalles Bibliográficos
Autores principales: Miller, Henry E., Gorthi, Aparna, Bassani, Nicklas, Lawrence, Liesl A., Iskra, Brian S., Bishop, Alexander J. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226175/
https://www.ncbi.nlm.nih.gov/pubmed/32290418
http://dx.doi.org/10.3390/cancers12040948

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226175/
https://www.ncbi.nlm.nih.gov/pubmed/32290418
http://dx.doi.org/10.3390/cancers12040948

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