Cargando…

Reconstruction of Ewing Sarcoma Developmental Context from Mass-Scale Transcriptomics Reveals Characteristics of EWSR1-FLI1 Permissibility

Ewing sarcoma is an aggressive pediatric cancer of enigmatic cellular origins typically resulting from a single translocation event t (11; 22) (q24; q12). The resulting fusion gene, EWSR1-FLI1, is toxic or unstable in most primary tissues. Consequently, attempts to model Ewing sarcomagenesis have pr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Miller, Henry E., Gorthi, Aparna, Bassani, Nicklas, Lawrence, Liesl A., Iskra, Brian S., Bishop, Alexander J. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226175/ https://www.ncbi.nlm.nih.gov/pubmed/32290418 http://dx.doi.org/10.3390/cancers12040948

Ejemplares similares

High Specificity of BCL11B and GLG1 for EWSR1-FLI1 and EWSR1-ERG Positive Ewing Sarcoma
por: Orth, Martin F., et al.
Publicado: (2020)

Knockdown of EWSR1/FLI1 expression alters the transcriptome of Ewing sarcoma cells in vitro
por: Wang, Jihan, et al.
Publicado: (2016)

Therapeutic Potential of EWSR1–FLI1 Inactivation by CRISPR/Cas9 in Ewing Sarcoma
por: Cervera, Saint T., et al.
Publicado: (2021)

Chromosomal localization of Ewing sarcoma EWSR1/FLI1 protein promotes the induction of aneuploidy
por: Park, Hyewon, et al.
Publicado: (2020)

Selective inhibition of HDAC6 regulates expression of the oncogenic driver EWSR1-FLI1 through the EWSR1 promoter in Ewing sarcoma
por: García-Domínguez, Daniel J., et al.
Publicado: (2021)

An inducible ectopic expression system of EWSR1-FLI1 as a tool for understanding Ewing sarcoma oncogenesis
por: García-Domínguez, Daniel J., et al.
Publicado: (2020)

RING1B recruits EWSR1-FLI1 and cooperates in the remodeling of chromatin necessary for Ewing sarcoma tumorigenesis
por: Sánchez-Molina, Sara, et al.
Publicado: (2020)

Cell-to-cell heterogeneity of EWSR1-FLI1 activity determines proliferation/migration choices in Ewing sarcoma cells
por: Franzetti, G-A, et al.
Publicado: (2017)

Complex/cryptic EWSR1::FLI1/ERG Gene Fusions and 1q Jumping Translocation in Pediatric Ewing Sarcomas
por: Zou, Ying S., et al.
Publicado: (2023)

Ewing sarcoma fusion oncogene: At the crossroads of transcription and DNA damage response
por: Gorthi, Aparna, et al.
Publicado: (2018)

Upregulation of NKX2.2, a target of EWSR1/FLI1 fusion transcript, in primary renal Ewing sarcoma
por: Yamamoto, Yoshinari, et al.
Publicado: (2015)

The Transcription Factor FEZF1, a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells, Regulates the Expression of Neural-Specific Genes
por: García-García, Laura, et al.
Publicado: (2021)

Splice variants denote differences between a cancer stem cell side population of EWSR1-ERG-based Ewing sarcoma cells, its main population and EWSR1-FLI-based cells
por: Korsching, Eberhard, et al.
Publicado: (2022)

TrkC, a novel prognostic marker, induces and maintains cell survival and metastatic dissemination of Ewing sarcoma by inhibiting EWSR1-FLI1 degradation
por: Kim, Min Soo, et al.
Publicado: (2022)

Ewing Sarcoma Protein Ewsr1 Maintains Mitotic Integrity and Proneural Cell Survival in the Zebrafish Embryo
por: Azuma, Mizuki, et al.
Publicado: (2007)

Robust diagnosis of Ewing sarcoma by immunohistochemical detection of super-enhancer-driven EWSR1-ETS targets
por: Baldauf, Michaela C., et al.
Publicado: (2017)

EWSR1 Rearrangement and CD99 Expression as Diagnostic Biomarkers for Ewing/PNET Sarcomas in a Moroccan Population
por: Louati, Sara, et al.
Publicado: (2018)

Aggressive myoepithelial carcinoma with EWSR1‐POU5F1 fusion highly responsive to Ewing sarcoma combination chemotherapy
por: Shenoy, Niraj
Publicado: (2020)

Primary Intracranial Ewing Sarcoma With EWSR1-FLI1 Gene Translocation Mimicking a Meningioma and a Multidisciplinary Therapeutic Approach: A Case Report and Systematic Review of Literatures
por: Hyun, Changjun, et al.
Publicado: (2023)

Downstream EWS/FLI1 - upstream Ewing's sarcoma
por: Kovar, Heinrich
Publicado: (2010)

Targeted Therapy for EWS-FLI1 in Ewing Sarcoma
por: Gong, Helong, et al.
Publicado: (2023)

Upregulation of the Mevalonate Pathway through EWSR1-FLI1/EGR2 Regulatory Axis Confers Ewing Cells Exquisite Sensitivity to Statins
por: Buchou, Charlie, et al.
Publicado: (2022)

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma
por: Herrero-Martin, David, et al.
Publicado: (2011)

Epigenetic control of the EWS-FLI1 promoter in Ewing's sarcoma
por: Montoya, C., et al.
Publicado: (2020)

Case report: Ewing sarcoma with EWSR–ERG fusion elevates procalcitonin extremely in the long term without infection
por: Chen, Ying, et al.
Publicado: (2023)

Overexpression of EWSR1 (Ewing sarcoma breakpoint region 1/EWS RNA binding protein 1) predicts poor survival in patients with hepatocellular carcinoma
por: Jiang, Weijie, et al.
Publicado: (2021)

Transformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1
por: Chan, D, et al.
Publicado: (2003)

EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma
por: Cidre-Aranaz, Florencia, et al.
Publicado: (2015)

The role of FLI-1-EWS, a fusion gene reciprocal to EWS-FLI-1, in Ewing sarcoma
por: Elzi, David J., et al.
Publicado: (2015)

Regulation of EWSR1-FLI1 Function by Post-Transcriptional and Post-Translational Modifications
por: Yu, Le, et al.
Publicado: (2023)

A Gammaherpesvirus MicroRNA Targets EWSR1 (Ewing Sarcoma Breakpoint Region 1) In Vivo To Promote Latent Infection of Germinal Center B Cells
por: Wang, Yiping, et al.
Publicado: (2019)

USP19 deubiquitinates EWS-FLI1 to regulate Ewing sarcoma growth
por: Gierisch, Maria E., et al.
Publicado: (2019)

EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma
por: Shi, Xianping, et al.
Publicado: (2020)

Cytopathological findings of primary pulmonary Ewing family of tumors with EWSR1 translocation: A case report
por: Mizuguchi, Keishi, et al.
Publicado: (2016)

Activity of pazopanib in EWSR1-NFATC2 translocation-associated bone sarcoma
por: Gouda, Mohamed A., et al.
Publicado: (2023)

Therapeutic opportunities in Ewing sarcoma: EWS-FLI inhibition via LSD1 targeting
por: Theisen, Emily R., et al.
Publicado: (2016)

EWS-FLI1 confers exquisite sensitivity to NAMPT inhibition in Ewing sarcoma cells
por: Mutz, Cornelia N., et al.
Publicado: (2017)

RNA Helicase DDX3 Regulates RAD51 Localization and DNA Damage Repair in Ewing Sarcoma
por: Randolph, Matthew E., et al.
Publicado: (2023)

Rationale for Early Detection of EWSR1 Translocation-Associated Sarcoma Biomarkers in Liquid Biopsy
por: Clanchy, Felix I. L.
Publicado: (2021)

EWS‐FLI1 regulates a transcriptional program in cooperation with Foxq1 in mouse Ewing sarcoma
por: Shimizu, Rikuka, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_elihik1hlb7b21445c4u7bcftp