The Roles of ROS Generation in RANKL-Induced Osteoclastogenesis: Suppressive Effects of Febuxostat

Receptor activator of NF-κB ligand (RANKL), a critical mediator of osteoclastogenesis, is upregulated in multiple myeloma (MM). The xanthine oxidase inhibitor febuxostat, clinically used for prevention of tumor lysis syndrome, has been demonstrated to effectively inhibit not only the generation of u...

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Detalles Bibliográficos
Autores principales: Ashtar, Mohannad, Tenshin, Hirofumi, Teramachi, Jumpei, Bat-Erdene, Ariunzaya, Hiasa, Masahiro, Oda, Asuka, Tanimoto, Kotaro, Shimizu, So, Higa, Yoshiki, Harada, Takeshi, Oura, Masahiro, Sogabe, Kimiko, Nakamura, Shingen, Fujii, Shiro, Sumitani, Ryohei, Miki, Hirokazu, Udaka, Kengo, Takahashi, Mamiko, Kagawa, Kumiko, Endo, Itsuro, Tanaka, Eiji, Matsumoto, Toshio, Abe, Masahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226249/
https://www.ncbi.nlm.nih.gov/pubmed/32283857
http://dx.doi.org/10.3390/cancers12040929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226249/
https://www.ncbi.nlm.nih.gov/pubmed/32283857
http://dx.doi.org/10.3390/cancers12040929

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