Cargando…

Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under Parg Deficiency

PolyADP-ribosylation is a post-translational modification of proteins, and poly(ADP-ribose) (PAR) polymerase (PARP) family proteins synthesize PAR using NAD as a substrate. Poly(ADP-ribose) glycohydrolase (PARG) functions as the main enzyme for the degradation of PAR. In this study, we investigated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sonoda, Yuki, Sasaki, Yuka, Gunji, Akemi, Shirai, Hidenori, Araki, Tomonori, Imamichi, Shoji, Onodera, Takae, Rydén, Anna-Margareta, Watanabe, Masatoshi, Itami, Jun, Honda, Takuya, Ashizawa, Kazuto, Nakao, Kazuhiko, Masutani, Mitsuko
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226256/ https://www.ncbi.nlm.nih.gov/pubmed/32344695 http://dx.doi.org/10.3390/cancers12041056

Ejemplares similares

A Combination of GM-CSF and Released Factors from Gamma-Irradiated Tumor Cells Enhances the Differentiation of Macrophages from Bone Marrow Cells and Their Antigen-Presenting Function and Polarization to Type 1
por: Chen, Lichao, et al.
Publicado: (2021)

Stability of centrosome numbers in poly(ADP-ribose) polymerase-1- and poly(ADP-ribose) glycohydrolase-deficient mouse ES cells
por: Ogino, Hideki, et al.
Publicado: (2004)

PARG dysfunction enhances DNA double strand break formation in S-phase after alkylation DNA damage and augments different cell death pathways
por: Shirai, H, et al.
Publicado: (2013)

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells
por: Ogino, Hideki, et al.
Publicado: (2007)

Loss of Parp-1 affects gene expression profile in a genome-wide manner in ES cells and liver cells
por: Ogino, Hideki, et al.
Publicado: (2007)

Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy
por: Imamichi, Shoji, et al.
Publicado: (2022)

Correction: Imamichi et al. Extracellular Release of HMGB1 as an Early Potential Biomarker for the Therapeutic Response in a Xenograft Model of Boron Neutron Capture Therapy. Biology 2022, 11, 420
por: Imamichi, Shoji, et al.
Publicado: (2023)

Radiosensitization to γ-Ray by Functional Inhibition of APOBEC3G
por: Tong, Ying, et al.
Publicado: (2022)

A tumorigenic culprit in ES cells
por: Wells, William A.
Publicado: (2003)

Comprehensive Phenotype of the p.Arg420his Allelic Form of Spinocerebellar Ataxia Type 13
por: Subramony, SH, et al.
Publicado: (2013)

Enhanced Cytotoxicity on Cancer Cells by Combinational Treatment of PARP Inhibitor and 5-Azadeoxycytidine Accompanying Distinct Transcriptional Profiles
por: Araki, Tomonori, et al.
Publicado: (2022)

PARP and PARG inhibitors in cancer treatment
por: Slade, Dea
Publicado: (2020)

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells
por: Roper, Stephen J., et al.
Publicado: (2014)

Evaluation of radioactivity in the bodies of mice induced by neutron exposure from an epi-thermal neutron source of an accelerator-based boron neutron capture therapy system
por: NAKAMURA, Satoshi, et al.
Publicado: (2017)

Proteomic Characterization of SAS Cell-Derived Extracellular Vesicles in Relation to Both BPA and Neutron Irradiation Doses
por: Perico, Davide, et al.
Publicado: (2023)

Eighteen-years follow-up of congenital hypothyroidism by TSHR gene p.Arg109Gln and p.Arg450His variants
por: Watanabe, Daisuke, et al.
Publicado: (2023)

The inhibition of PARG attenuates DNA repair in hepatocellular carcinoma
por: Geng, Longpo, et al.
Publicado: (2023)

PARP1 gene expression is downregulated by knockdown of PARG gene
por: UCHIUMI, FUMIAKI, et al.
Publicado: (2013)

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells
por: James, Dominic I., et al.
Publicado: (2016)

O-GlcNAc has crosstalk with ADP-ribosylation via PARG
por: Li, Jie, et al.
Publicado: (2023)

Characterization of the relationship between neutron production and thermal load on a target material in an accelerator-based boron neutron capture therapy system employing a solid-state Li target
por: Nakamura, Satoshi, et al.
Publicado: (2019)

Dabigatran‐induced esophagitis with full circumferential blue pigmentation
por: Araki, Tomonori, et al.
Publicado: (2023)

Novel myophosphorylase mutation (p.Arg94Pro) with progressive exercise intolerance
por: Nabavi Nouri, Maryam, et al.
Publicado: (2018)

A novel non-canonical PIP-box mediates PARG interaction with PCNA
por: Kaufmann, Tanja, et al.
Publicado: (2017)

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency
por: Noll, Aurélia, et al.
Publicado: (2016)

Phospholamban p.Arg14del Cardiomyopathy: A Japanese Case Series
por: Tabata, Tomoka, et al.
Publicado: (2021)

Relative biological effectiveness for epithermal neutron beam contaminated with fast neutrons in the linear accelerator-based boron neutron capture therapy system coupled to a solid-state lithium target
por: Nakamura, Satoshi, et al.
Publicado: (2023)

ADP-Ribosylation as Post-Translational Modification of Proteins: Use of Inhibitors in Cancer Control
por: Poltronieri, Palmiro, et al.
Publicado: (2021)

Investigation of PARP-1, PARP-2, and PARG interactomes by affinity-purification mass spectrometry
por: Isabelle, Maxim, et al.
Publicado: (2010)

The phospholamban p.Arg14del founder mutation in Dutch patients with arrhythmogenic cardiomyopathy
por: van der Heijden, J. F., et al.
Publicado: (2013)

Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors
por: Sahaboglu, A, et al.
Publicado: (2014)

Venous thromboembolism is caused by prothrombin p.Arg541Trp mutation in Japanese individuals
por: Yamamoto, Jumpei, et al.
Publicado: (2021)

Pseudoangiomatous retinal gliosis (PARG) treated with iodine plaque in patient with chronic retinal detachment
por: Marquez, Marilyn A., et al.
Publicado: (2022)

PARP Inhibitor Decreases Akt Phosphorylation and Induces Centrosome Amplification and Chromosomal Aneuploidy in CHO-K1 Cells
por: Tanaka, Masakazu, et al.
Publicado: (2022)

Neutron flux evaluation model provided in the accelerator-based boron neutron capture therapy system employing a solid-state lithium target
por: Nakamura, Satoshi, et al.
Publicado: (2021)

PARG is recruited to DNA damage sites through poly(ADP-ribose)- and PCNA-dependent mechanisms
por: Mortusewicz, Oliver, et al.
Publicado: (2011)

Structural and Population-Based Evaluations of TBC1D1 p.Arg125Trp
por: Richardson, Tom G., et al.
Publicado: (2013)

Lung function and disease severity in cystic fibrosis patients heterozygous for p.Arg117His
por: Shteinberg, Michal, et al.
Publicado: (2017)

TP53 p.Arg337His geographic distribution correlates with adrenocortical tumor occurrence
por: Seidinger, Ana L., et al.
Publicado: (2020)

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
por: Houl, Jerry H., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_ou1300dfs9jgesdoahujgfpun5