The Influence of Varying Fluorination Patterns on the Thermodynamics and Kinetics of Benzenesulfonamide Binding to Human Carbonic Anhydrase II

The fluorination of lead-like compounds is a common tool in medicinal chemistry to alter molecular properties in various ways and with different goals. We herein present a detailed study of the binding of fluorinated benzenesulfonamides to human Carbonic Anhydrase II by complementing macromolecular...

Descripción completa

Detalles Bibliográficos
Autores principales: Glöckner, Steffen, Ngo, Khang, Wagner, Björn, Heine, Andreas, Klebe, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226267/
https://www.ncbi.nlm.nih.gov/pubmed/32230853
http://dx.doi.org/10.3390/biom10040509

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226267/
https://www.ncbi.nlm.nih.gov/pubmed/32230853
http://dx.doi.org/10.3390/biom10040509

Ejemplares similares