Iron Causes Lipid Oxidation and Inhibits Proteasome Function in Multiple Myeloma Cells: A Proof of Concept for Novel Combination Therapies

Adaptation to import iron for proliferation makes cancer cells potentially sensitive to iron toxicity. Iron loading impairs multiple myeloma (MM) cell proliferation and increases the efficacy of the proteasome inhibitor bortezomib. Here, we defined the mechanisms of iron toxicity in MM.1S, U266, H92...

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Detalles Bibliográficos
Autores principales: Bordini, Jessica, Morisi, Federica, Cerruti, Fulvia, Cascio, Paolo, Camaschella, Clara, Ghia, Paolo, Campanella, Alessandro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226326/
https://www.ncbi.nlm.nih.gov/pubmed/32295216
http://dx.doi.org/10.3390/cancers12040970

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226326/
https://www.ncbi.nlm.nih.gov/pubmed/32295216
http://dx.doi.org/10.3390/cancers12040970

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