Matriptase Cleaves EpCAM and TROP2 in Keratinocytes, Destabilizing Both Proteins and Associated Claudins

The homologs EpCAM and TROP2, which both interact with claudin-1 and claudin-7, are frequently coexpressed in epithelia including skin. Intestine uniquely expresses high levels of EpCAM but not TROP2. We previously identified EpCAM as a substrate of the membrane-anchored protease matriptase and link...

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Detalles Bibliográficos
Autores principales: Wu, Chuan-Jin, Lu, Michael, Feng, Xu, Nakato, Gaku, Udey, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226414/
https://www.ncbi.nlm.nih.gov/pubmed/32326212
http://dx.doi.org/10.3390/cells9041027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226414/
https://www.ncbi.nlm.nih.gov/pubmed/32326212
http://dx.doi.org/10.3390/cells9041027

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