PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR

Phenylbutyrate (PBA) is a derivative of Butyric Acid (BA), which has the characteristics of being a histone deacetylase (HDAC) inhibitor and acting as a chemical chaperone. It has the potential to counteract a variety of different diseases, from neurodegeneration to cancer. In this study, we investi...

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Detalles Bibliográficos
Autores principales: Romeo, Maria Anele, Gilardini Montani, Maria Saveria, Benedetti, Rossella, Garufi, Alessia, D’Orazi, Gabriella, Cirone, Mara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226434/
https://www.ncbi.nlm.nih.gov/pubmed/32290231
http://dx.doi.org/10.3390/biom10040586

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226434/
https://www.ncbi.nlm.nih.gov/pubmed/32290231
http://dx.doi.org/10.3390/biom10040586

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