Exploring the Synergy between PARP and CHK1 Inhibition in Matched BRCA2 Mutant and Corrected Cells

PARP inhibition results in the accumulation of DNA SSBs, causing replication stress (RS) and lesions that can only be resolved by homologous recombination repair (HRR). Defects in HRR, e.g., due to BRCA2 mutation, confer profound sensitivity to PARP inhibitor (PARPi) cytotoxicity. In response to RS,...

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Detalles Bibliográficos
Autores principales: Smith, Hannah L, Prendergast, Lisa, Curtin, Nicola J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226483/
https://www.ncbi.nlm.nih.gov/pubmed/32260355
http://dx.doi.org/10.3390/cancers12040878

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226483/
https://www.ncbi.nlm.nih.gov/pubmed/32260355
http://dx.doi.org/10.3390/cancers12040878

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