Insights into P-Glycoprotein Inhibitors: New Inducers of Immunogenic Cell Death

Doxorubicin is a strong inducer of immunogenic cell death (ICD), but it is ineffective in P-glycoprotein (Pgp)-expressing cells. Indeed, Pgp effluxes doxorubicin and impairs the immunesensitizing functions of calreticulin (CRT), an “eat-me” signal mediating ICD. It is unknown if classical Pgp inhibi...

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Detalles Bibliográficos
Autores principales: Kopecka, Joanna, Godel, Martina, Dei, Silvia, Giampietro, Roberta, Belisario, Dimas Carolina, Akman, Muhlis, Contino, Marialessandra, Teodori, Elisabetta, Riganti, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226521/
https://www.ncbi.nlm.nih.gov/pubmed/32331368
http://dx.doi.org/10.3390/cells9041033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226521/
https://www.ncbi.nlm.nih.gov/pubmed/32331368
http://dx.doi.org/10.3390/cells9041033

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