The Core-Clock Gene NR1D1 Impacts Cell Motility In Vitro and Invasiveness in a Zebrafish Xenograft Colon Cancer Model

Malfunctions of circadian clock trigger abnormal cellular processes and influence tumorigenesis. Using an in vitro and in vivo xenograft model, we show that circadian clock disruption via the downregulation of the core-clock genes BMAL1, PER2, and NR1D1 impacts the circadian phenotype of MYC, WEE1,...

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Detalles Bibliográficos
Autores principales: Basti, Alireza, Fior, Rita, Yalҫin, Müge, Póvoa, Vanda, Astaburuaga, Rosario, Li, Yin, Naderi, Julian, Godinho Ferreira, Miguel, Relógio, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226575/
https://www.ncbi.nlm.nih.gov/pubmed/32244760
http://dx.doi.org/10.3390/cancers12040853

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226575/
https://www.ncbi.nlm.nih.gov/pubmed/32244760
http://dx.doi.org/10.3390/cancers12040853

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