In Vitro Activation of Cytochrome P450 46A1 (CYP46A1) by Efavirenz-Related Compounds

[Image: see text] Cytochrome P450 46A1 (CYP46A1) is a central nervous system-specific enzyme, which catalyzes cholesterol 24-hydroxylation. Currently CYP46A1 is being evaluated in a clinical trial for activation by small doses of the anti-HIV drug efavirenz. Eight efavirenz-related compounds were in...

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Detalles Bibliográficos
Autores principales: Mast, Natalia, Verwilst, Peter, Wilkey, Clayton J., Guengerich, F. Peter, Pikuleva, Irina A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226586/
https://www.ncbi.nlm.nih.gov/pubmed/31617715
http://dx.doi.org/10.1021/acs.jmedchem.9b01383

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226586/
https://www.ncbi.nlm.nih.gov/pubmed/31617715
http://dx.doi.org/10.1021/acs.jmedchem.9b01383

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