P66Shc: A Pleiotropic Regulator of B Cell Trafficking and a Gatekeeper in Chronic Lymphocytic Leukemia

Neoplastic B cells from chronic lymphocytic leukemia patients (CLL) have a profound deficiency in the expression of p66Shc, an adaptor protein with pro-apoptotic and pro-oxidant activities. This defect results in leukemic B cell resistance to apoptosis and additionally impinges on the balance betwee...

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Detalles Bibliográficos
Autores principales: Patrussi, Laura, Capitani, Nagaja, Baldari, Cosima T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226591/
https://www.ncbi.nlm.nih.gov/pubmed/32325830
http://dx.doi.org/10.3390/cancers12041006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226591/
https://www.ncbi.nlm.nih.gov/pubmed/32325830
http://dx.doi.org/10.3390/cancers12041006

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