Cargando…

Exploring Biased Agonism at FPR1 as a Means to Encode Danger Sensing †

Ligand-based selectivity in signal transduction (biased signaling) is an emerging field of G protein-coupled receptor (GPCR) research and might allow the development of drugs with targeted activation profiles. Human formyl peptide receptor 1 (FPR1) is a GPCR that detects potentially hazardous states...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gröper, Jieny, König, Gabriele M., Kostenis, Evi, Gerke, Volker, Raabe, Carsten A., Rescher, Ursula
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226602/ https://www.ncbi.nlm.nih.gov/pubmed/32340221 http://dx.doi.org/10.3390/cells9041054

Ejemplares similares

The annexin A1/FPR2 signaling axis expands alveolar macrophages, limits viral replication, and attenuates pathogenesis in the murine influenza A virus infection model
por: Schloer, Sebastian, et al.
Publicado: (2019)

Biased agonism
por: Kenakin, Terry
Publicado: (2009)

A Pharmacological Primer of Biased Agonism
por: Andresen, Bradley T
Publicado: (2011)

Disentangling bias between G(q), GRK2, and arrestin3 recruitment to the M(3) muscarinic acetylcholine receptor
por: Flöser, Anja, et al.
Publicado: (2021)

Selective FPR2 Agonism Promotes a Proresolution Macrophage Phenotype and Improves Cardiac Structure-Function Post Myocardial Infarction
por: García, Ricardo A., et al.
Publicado: (2021)

Biased agonism: the quest for the analgesic holy grail
por: Stanczyk, M. Alexander, et al.
Publicado: (2018)

FPR Ligands
por: Liu, Ying, et al.
Publicado: (2013)

The role of kinetic context in apparent biased agonism at GPCRs
por: Klein Herenbrink, Carmen, et al.
Publicado: (2016)

The therapeutic potential of GLP‐1 receptor biased agonism
por: Jones, Ben
Publicado: (2021)

A structural mechanism of nuclear receptor biased agonism
por: Nemetchek, Michelle D., et al.
Publicado: (2022)

Annexin A1 released from apoptotic cells acts through formyl peptide receptors to dampen inflammatory monocyte activation via JAK/STAT/SOCS signalling
por: Pupjalis, Danute, et al.
Publicado: (2011)

Special Issue “Recent Developments in Annexin Biology”
por: Rescher, Ursula, et al.
Publicado: (2020)

The Mammalian Orthologs of Drosophila Lgd, CC2D1A and CC2D1B, Function in the Endocytic Pathway, but Their Individual Loss of Function Does Not Affect Notch Signalling
por: Drusenheimer, Nadja, et al.
Publicado: (2015)

Biased versus Partial Agonism in the Search for Safer Opioid Analgesics
por: Azevedo Neto, Joaquim, et al.
Publicado: (2020)

Ligand recognition and biased agonism of the D1 dopamine receptor
por: Teng, Xiao, et al.
Publicado: (2022)

Meaning of dangerous goods
Publicado: (2008)

Molecular recognition of formylpeptides and diverse agonists by the formylpeptide receptors FPR1 and FPR2
por: Zhuang, Youwen, et al.
Publicado: (2022)

The Role of Water in Activation Mechanism of Human N-Formyl Peptide Receptor 1 (FPR1) Based on Molecular Dynamics Simulations
por: Yuan, Shuguang, et al.
Publicado: (2012)

A Complementary Scale of Biased Agonism for Agonists with Differing Maximal Responses
por: Burgueño, Javier, et al.
Publicado: (2017)

Annexin Animal Models—From Fundamental Principles to Translational Research
por: Grewal, Thomas, et al.
Publicado: (2021)

Annexin A6-Balanced Late Endosomal Cholesterol Controls Influenza A Replication and Propagation
por: Musiol, Agnes, et al.
Publicado: (2013)

Negativity Bias in Dangerous Drivers
por: Chai, Jing, et al.
Publicado: (2016)

Molecular mechanism of agonism and inverse agonism in ghrelin receptor
por: Qin, Jiao, et al.
Publicado: (2022)

Biased Agonism of Three Different Cannabinoid Receptor Agonists in Mouse Brain Cortex
por: Diez-Alarcia, Rebeca, et al.
Publicado: (2016)

A Practical Guide to Approaching Biased Agonism at G Protein Coupled Receptors
por: Gundry, Jaimee, et al.
Publicado: (2017)

Modelling and simulation of biased agonism dynamics at a G protein-coupled receptor
por: Bridge, L.J., et al.
Publicado: (2018)

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism
por: Wootten, Denise, et al.
Publicado: (2016)

Mitocryptide-2: Identification of Its Minimum Structure for Specific Activation of FPR2–Possible Receptor Switching from FPR2 to FPR1 by Its Physiological C-terminal Cleavages
por: Marutani, Takayuki, et al.
Publicado: (2021)

Agonizing Hedgehog
por: Weitzman, Jonathan B
Publicado: (2002)

Agonist concentration–dependent changes in FPR1 conformation lead to biased signaling for selective activation of phagocyte functions
por: Wang, Junlin, et al.
Publicado: (2022)

Encoding of danger by parabrachial CGRP neurons
por: Campos, Carlos A., et al.
Publicado: (2018)

Agon : ballet for twelve dancers
por: Stravinsky, Igor, 1882-1971
Publicado: (1957)

RXFP1 Receptor Activation by Relaxin-2 Induces Vascular Relaxation in Mice via a Gα(i2)-Protein/PI3Kß/γ/Nitric Oxide-Coupled Pathway
por: Lian, Xiaoming, et al.
Publicado: (2018)

Oxytocin-Modulated Ion Channel Ensemble Controls Depolarization, Integration and Burst Firing in CA2 Pyramidal Neurons
por: Liu, Jing-Jing, et al.
Publicado: (2022)

Influence of Chemokine N-Terminal Modification on Biased Agonism at the Chemokine Receptor CCR1
por: Sanchez, Julie, et al.
Publicado: (2019)

Cellular Electrical Impedance as a Method to Decipher CCR7 Signalling and Biased Agonism
por: Vanalken, Nathan, et al.
Publicado: (2022)

Regulation of retinal pigment epithelial cell phenotype by Annexin A8
por: Lueck, Katharina, et al.
Publicado: (2017)

Targeting the endolysosomal host-SARS-CoV-2 interface by clinically licensed functional inhibitors of acid sphingomyelinase (FIASMA) including the antidepressant fluoxetine
por: Schloer, Sebastian, et al.
Publicado: (2020)

The ambiguous role of FPR1 in immunity and inflammation
por: Vacchelli, Erika, et al.
Publicado: (2020)

A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique G(i)-functional Bias
por: Bolognini, Daniele, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_06v5snvq741fb1mn63l1vsh433