Cargando…

Time- and Dose-Dependent Effects of Ionizing Irradiation on the Membrane Expression of Hsp70 on Glioma Cells

The major stress-inducible protein Hsp70 (HSPA1A) is overexpressed in the cytosol of many highly aggressive tumor cells including glioblastoma multiforme and presented on their plasma membrane. Depending on its intracellular or membrane localization, Hsp70 either promotes tumor growth or serves as a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fellinger, Helena, Stangl, Stefan, Hernandez Schnelzer, Alicia, Schwab, Melissa, Di Genio, Tommaso, Pieper, Marija, Werner, Caroline, Shevtsov, Maxim, Haller, Bernhard, Multhoff, Gabriele
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226755/ https://www.ncbi.nlm.nih.gov/pubmed/32276468 http://dx.doi.org/10.3390/cells9040912

Ejemplares similares

Membrane Hsp70-supported cell-to-cell connections via tunneling nanotubes revealed by live-cell STED nanoscopy
por: Reindl, Judith, et al.
Publicado: (2019)

Functionalized Hybrid Iron Oxide–Gold Nanoparticles Targeting Membrane Hsp70 Radiosensitize Triple-Negative Breast Cancer Cells by ROS-Mediated Apoptosis
por: Wu, Zhiyuan, et al.
Publicado: (2023)

Hsp70 in Liquid Biopsies—A Tumor-Specific Biomarker for Detection and Response Monitoring in Cancer
por: Werner, Caroline, et al.
Publicado: (2021)

Potential Role of Hsp70 and Activated NK Cells for Prediction of Prognosis in Glioblastoma Patients
por: Lobinger, Dominik, et al.
Publicado: (2021)

Gold Nanoparticle Mediated Multi-Modal CT Imaging of Hsp70 Membrane-Positive Tumors
por: Kimm, Melanie A., et al.
Publicado: (2020)

Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer
por: Shevtsov, Maxim, et al.
Publicado: (2019)

CAR T Cells Targeting Membrane-Bound Hsp70 on Tumor Cells Mimic Hsp70-Primed NK Cells
por: Bashiri Dezfouli, Ali, et al.
Publicado: (2022)

Heat Shock Protein–Peptide and HSP-Based Immunotherapies for the Treatment of Cancer
por: Shevtsov, Maxim, et al.
Publicado: (2016)

Imaging of Hsp70-positive tumors with cmHsp70.1 antibody-conjugated gold nanoparticles
por: Gehrmann, Mathias K, et al.
Publicado: (2015)

7Hsp70 serum levels in pet dogs—a potential diagnostic biomarker for spontaneous round cell tumors
por: Salvermoser, Lukas, et al.
Publicado: (2019)

Comparing TIMP-1 and Hsp70 in Blood and Saliva as Potential Prognostic Markers in HNSCC
por: Rinecker, Jakob, et al.
Publicado: (2022)

Membrane heat shock protein 70: a theranostic target for cancer therapy
por: Shevtsov, Maxim, et al.
Publicado: (2018)

Cannabidiol-induced crosstalk of apoptosis and macroautophagy in colorectal cancer cells involves p53 and Hsp70
por: Wang, Fei, et al.
Publicado: (2023)

Role of membrane Hsp70 in radiation sensitivity of tumor cells
por: Murakami, Naoya, et al.
Publicado: (2015)

A Low Membrane Hsp70 Expression in Tumor Cells With Impaired Lactate Metabolism Mediates Radiosensitization by NVP-AUY922
por: Schwab, Melissa, et al.
Publicado: (2022)

Tumor Imaging and Targeting Potential of an Hsp70-Derived 14-Mer Peptide
por: Gehrmann, Mathias, et al.
Publicado: (2014)

Targeting Cancer Metabolism Breaks Radioresistance by Impairing the Stress Response
por: Schwab, Melissa, et al.
Publicado: (2021)

Immunotherapeutic Targeting of Membrane Hsp70-Expressing Tumors Using Recombinant Human Granzyme B
por: Gehrmann, Mathias, et al.
Publicado: (2012)

Membrane Hsp70—A Novel Target for the Isolation of Circulating Tumor Cells After Epithelial-to-Mesenchymal Transition
por: Breuninger, Stephanie, et al.
Publicado: (2018)

In vivo imaging of CT26 mouse tumours by using cmHsp70.1 monoclonal antibody
por: Stangl, Stefan, et al.
Publicado: (2011)

Radiosensitization of HSF-1 Knockdown Lung Cancer Cells by Low Concentrations of Hsp90 Inhibitor NVP-AUY922
por: Kühnel, Annett, et al.
Publicado: (2019)

A New Pharmacokinetic Model Describing the Biodistribution of Intravenously and Intratumorally Administered Superparamagnetic Iron Oxide Nanoparticles (SPIONs) in a GL261 Xenograft Glioblastoma Model
por: Klapproth, Alexander P, et al.
Publicado: (2020)

Increased heat shock protein 70 (Hsp70) serum levels and low NK cell counts after radiotherapy – potential markers for predicting breast cancer recurrence?
por: Rothammer, Anna, et al.
Publicado: (2019)

Targeted Hsp70 fluorescence molecular endoscopy detects dysplasia in Barrett’s esophagus
por: Fang, Hsin-Yu, et al.
Publicado: (2021)

Elevated circulating Hsp70 levels are correlative for malignancies in different mammalian species
por: Salvermoser, Lukas, et al.
Publicado: (2022)

A new look at Hsp70 activity in phosphatidylserine-enriched membranes: chaperone-induced quasi-interdigitated lipid phase
por: Tagaeva, Ruslana, et al.
Publicado: (2023)

Immunological and Translational Aspects of NK Cell-Based Antitumor Immunotherapies
por: Shevtsov, Maxim, et al.
Publicado: (2016)

Correction to: Elevated circulating Hsp70 levels are correlative for malignancies in different mammalian species
por: Salvermoser, Lukas, et al.
Publicado: (2022)

X-ray reflectivity study of the heat shock protein Hsp70 interaction with an artificial cell membrane model
por: Makky, Ali, et al.
Publicado: (2023)

Human granzyme B binds Plasmodium falciparum Hsp70-x and mediates antiplasmodial activity in vitro
por: Ramatsui, Lebogang, et al.
Publicado: (2023)

Tumor-Specific Hsp70 Plasma Membrane Localization Is Enabled by the Glycosphingolipid Gb3
por: Gehrmann, Mathias, et al.
Publicado: (2008)

Plasmodium falciparum-Infected Erythrocytes Induce Granzyme B by NK Cells through Expression of Host-Hsp70
por: Böttger, Evelyn, et al.
Publicado: (2012)

Correlation of Hsp70 Serum Levels with Gross Tumor Volume and Composition of Lymphocyte Subpopulations in Patients with Squamous Cell and Adeno Non-Small Cell Lung Cancer
por: Gunther, Sophie, et al.
Publicado: (2015)

Radioresistance of human glioma spheroids and expression of HSP70, p53 and EGFr
por: Fedrigo, Carlos A, et al.
Publicado: (2011)

Hsp70 gene association with nuclear speckles is Hsp70 promoter specific
por: Hu, Yan, et al.
Publicado: (2010)

Hsp70 - a biomarker for tumor detection and monitoring of outcome of radiation therapy in patients with squamous cell carcinoma of the head and neck
por: Gehrmann, Mathias, et al.
Publicado: (2014)

The Effects of Venlafaxine and Dexamethasone on the Expression of HSP70 in Rat C6 Glioma Cells
por: Yu, Jaehak, et al.
Publicado: (2010)

Synthetic Small Molecule Modulators of Hsp70 and Hsp40 Chaperones as Promising Anticancer Agents
por: Nitzsche, Bianca, et al.
Publicado: (2023)

Novel Approaches to Improve the Efficacy of Immuno-Radiotherapy
por: Shevtsov, Maxim, et al.
Publicado: (2019)

Expressions of HSP70 and HSP27 in Hepatocellular Carcinoma
por: Joo, Mee, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_lse71v5amvomt6kflk0hgm95eu