Human Alphoid(tetO) Artificial Chromosome as a Gene Therapy Vector for the Developing Hemophilia A Model in Mice

Human artificial chromosomes (HACs), including the de novo synthesized alphoid(tetO)-HAC, are a powerful tool for introducing genes of interest into eukaryotic cells. HACs are mitotically stable, non-integrative episomal units that have a large transgene insertion capacity and allow efficient and st...

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Detalles Bibliográficos
Autores principales: Ponomartsev, Sergey V., Sinenko, Sergey A., Skvortsova, Elena V., Liskovykh, Mikhail A., Voropaev, Ivan N., Savina, Maria M., Kuzmin, Andrey A., Kuzmina, Elena Yu., Kondrashkina, Alexandra M., Larionov, Vladimir, Kouprina, Natalay, Tomilin, Alexey N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226776/
https://www.ncbi.nlm.nih.gov/pubmed/32260189
http://dx.doi.org/10.3390/cells9040879

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226776/
https://www.ncbi.nlm.nih.gov/pubmed/32260189
http://dx.doi.org/10.3390/cells9040879

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