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Design, Synthesis, and Antimicrobial Evaluation of a New Series of N-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes

[Image: see text] Sulfonamides and trimethoprim (TMP) drugs are normally used to inhibit the action of dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) enzymes, respectively. In this work, a new series of N-sulfonamide 2-pyridone derivatives that combine the inhibitory activities o...

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Detalles Bibliográficos
Autores principales: Azzam, Rasha A., Elsayed, Rasha E., Elgemeie, Galal H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226860/
https://www.ncbi.nlm.nih.gov/pubmed/32426597
http://dx.doi.org/10.1021/acsomega.0c00280