hnRNP A1 Regulates Alternative Splicing of Tau Exon 10 by Targeting 3′ Splice Sites

The ratio control of 4R-Tau/3R-Tau by alternative splicing of Tau exon 10 is important for maintaining brain functions. In this study, we show that hnRNP A1 knockdown induces inclusion of endogenous Tau exon 10, conversely, overexpression of hnRNP A1 promotes exon 10 skipping of Tau. In addition, hn...

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Detalles Bibliográficos
Autores principales: Liu, Yongchao, Kim, Donggun, Choi, Namjeong, Oh, Jagyeong, Ha, Jiyeon, Zhou, Jianhua, Zheng, Xuexiu, Shen, Haihong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226981/
https://www.ncbi.nlm.nih.gov/pubmed/32290247
http://dx.doi.org/10.3390/cells9040936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226981/
https://www.ncbi.nlm.nih.gov/pubmed/32290247
http://dx.doi.org/10.3390/cells9040936

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