Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate

The breakdown of the endothelial cell (EC) barrier contributes significantly to sepsis mortality. Sphingosine 1-phosphate (S1P) is one of the most effective EC barrier-stabilizing signaling molecules. Stabilization is mainly transduced via the S1P receptor type 1 (S1PR1). Here, we demonstrate that S...

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Detalles Bibliográficos
Autores principales: Jeya Paul, Jefri, Weigel, Cynthia, Müller, Tina, Heller, Regine, Spiegel, Sarah, Gräler, Markus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226983/
https://www.ncbi.nlm.nih.gov/pubmed/32290092
http://dx.doi.org/10.3390/cells9040928

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226983/
https://www.ncbi.nlm.nih.gov/pubmed/32290092
http://dx.doi.org/10.3390/cells9040928

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