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Inflammatory Conditions Disrupt Constitutive Endothelial Cell Barrier Stabilization by Alleviating Autonomous Secretion of Sphingosine 1-Phosphate

The breakdown of the endothelial cell (EC) barrier contributes significantly to sepsis mortality. Sphingosine 1-phosphate (S1P) is one of the most effective EC barrier-stabilizing signaling molecules. Stabilization is mainly transduced via the S1P receptor type 1 (S1PR1). Here, we demonstrate that S...

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Detalles Bibliográficos
Autores principales:	Jeya Paul, Jefri, Weigel, Cynthia, Müller, Tina, Heller, Regine, Spiegel, Sarah, Gräler, Markus H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226983/ https://www.ncbi.nlm.nih.gov/pubmed/32290092 http://dx.doi.org/10.3390/cells9040928

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