The DNA Sensor AIM2 Protects against Streptozotocin-Induced Type 1 Diabetes by Regulating Intestinal Homeostasis via the IL-18 Pathway

Pattern recognition receptors (PRRs), such as Nod2, Nlrp3, Tlr2, Trl4, and Tlr9, are directly involved in type 1 diabetes (T1D) susceptibility. However, the role of the cytosolic DNA sensor, AIM2, in T1D pathogenesis is still unknown. Here, we demonstrate that C57BL/6 mice lacking AIM2 (AIM2(−/−)) a...

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Detalles Bibliográficos
Autores principales: Leite, Jefferson Antônio, Pessenda, Gabriela, Guerra-Gomes, Isabel C., de Santana, Alynne Karen Mendonça, André Pereira, Camila, Ribeiro Campos Costa, Frederico, Ramos, Simone G., Simões Zamboni, Dario, Caetano Faria, Ana Maria, Candido de Almeida, Danilo, Olsen Saraiva Câmara, Niels, Tostes, Rita C., Santana Silva, João, Carlos, Daniela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227011/
https://www.ncbi.nlm.nih.gov/pubmed/32295112
http://dx.doi.org/10.3390/cells9040959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227011/
https://www.ncbi.nlm.nih.gov/pubmed/32295112
http://dx.doi.org/10.3390/cells9040959

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