Cargando…

Upregulation of pERK and c-JUN by γ-tocotrienol and not α-tocopherol are essential to the differential effect on apoptosis in prostate cancer cells

BACKGROUND: α-tocopherol (AT) and γ-tocotrienol (GT3) are vitamin E isoforms considered to have potential chemopreventive properties. AT has been widely studied in vitro and in clinical trials with mixed results. The latest clinical study (SELECT trial) tested AT in prostate cancer patients, determi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Moore, Christine, Palau, Victoria E., Mahboob, Rashid, Lightner, Janet, Stone, William, Krishnan, Koyamangalath
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227069/ https://www.ncbi.nlm.nih.gov/pubmed/32414345 http://dx.doi.org/10.1186/s12885-020-06947-6

Ejemplares similares

γ-Tocotrienol induces apoptosis in pancreatic cancer cells by upregulation of ceramide synthesis and modulation of sphingolipid transport
por: Palau, Victoria E., et al.
Publicado: (2018)

Gamma (γ) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (γ) expression in SW 480 human colon cancer cell lines
por: Campbell, Sharon E, et al.
Publicado: (2003)

The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro
por: Ibrahim, Nor Faeizah, et al.
Publicado: (2021)

Tocopherol and tocotrienol homologs in parenteral lipid emulsions
por: Xu, Zhidong, et al.
Publicado: (2015)

An Update on Vitamin E, Tocopherol and Tocotrienol—Perspectives
por: Colombo, Maria Laura
Publicado: (2010)

α-Tocopherol transfer protein does not regulate the cellular uptake and intracellular distribution of α- and γ-tocopherols and -tocotrienols in cultured liver cells
por: Irías-Mata, Andrea, et al.
Publicado: (2018)

Attenuation of lipopolysaccharide (LPS)-induced cytotoxicity by tocopherols and tocotrienols()
por: Nishio, Keiko, et al.
Publicado: (2013)

Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures
por: Singh, Vijay K., et al.
Publicado: (2013)

Rice antioxidants: phenolic acids, flavonoids, anthocyanins, proanthocyanidins, tocopherols, tocotrienols, γ-oryzanol, and phytic acid
por: Goufo, Piebiep, et al.
Publicado: (2014)

The difference in the cellular uptake of tocopherol and tocotrienol is influenced by their affinities to albumin
por: Nakatomi, Takashi, et al.
Publicado: (2023)

γ-Tocotrienol and α-Tocopherol Ether Acetate Enhance Docetaxel Activity in Drug-Resistant Prostate Cancer Cells
por: Asay, Spencer, et al.
Publicado: (2020)

Tocopherols and Tocotrienols—Bioactive Dietary Compounds; What Is Certain, What Is Doubt?
por: Szewczyk, Kacper, et al.
Publicado: (2021)

Doxorubicin Induces Cytotoxicity through Upregulation of pERK–Dependent ATF3
por: Park, Eun-Jung, et al.
Publicado: (2012)

Towards the interaction mechanism of tocopherols and tocotrienols (vitamin E) with selected metabolizing enzymes
por: Upadhyay, Jyoti, et al.
Publicado: (2009)

Tocopherols and Tocotrienols in Common and Emerging Dietary Sources: Occurrence, Applications, and Health Benefits
por: Shahidi, Fereidoon, et al.
Publicado: (2016)

Tocopherols, tocotrienols and tocomonoenols: Many similar molecules but only one vitamin E
por: Azzi, Angelo
Publicado: (2019)

Methods for efficient analysis of tocopherols, tocotrienols and their metabolites in animal samples with HPLC-EC
por: Lee, Mao-Jung, et al.
Publicado: (2017)

Comparative effects of RRR-alpha- and RRR-gamma-tocopherol on proliferation and apoptosis in human colon cancer cell lines
por: Campbell, Sharon E, et al.
Publicado: (2006)

The Tocotrienol-Rich Fraction Is Superior to Tocopherol in Promoting Myogenic Differentiation in the Prevention of Replicative Senescence of Myoblasts
por: Khor, Shy Cian, et al.
Publicado: (2016)

Assessing the Impact of Oil Types and Grades on Tocopherol and Tocotrienol Contents in Vegetable Oils with Chemometric Methods
por: Wen, Yunqi, et al.
Publicado: (2020)

Comparing Palm Oil, Tocotrienol-Rich Fraction and α-Tocopherol Supplementation on the Antioxidant Levels of Older Adults
por: Nor Azman, Nor Helwa Ezzah, et al.
Publicado: (2018)

Suppression of Amyloid-β Adsorption on Endoplasmic Reticulum Stress-Mimicking Membranes by α-Tocopherol and α-Tocotrienol
por: Nakatani, Yusuke, et al.
Publicado: (2022)

Location of α-tocopherol and α-tocotrienol to heterogeneous cell membranes and inhibition of production of peroxidized cholesterol in mouse fibroblasts
por: Nakamura, Toshiyuki, et al.
Publicado: (2014)

Focus on Pivotal Role of Dietary Intake (Diet and Supplement) and Blood Levels of Tocopherols and Tocotrienols in Obtaining Successful Aging
por: Rondanelli, Mariangela, et al.
Publicado: (2015)

Dietary Vitamin E Isoforms Intake: Development of a New Tool to Assess Tocopherols and Tocotrienols Intake in Adults
por: Szewczyk, Kacper, et al.
Publicado: (2023)

The Modulation of NMDA and AMPA/Kainate Receptors by Tocotrienol-Rich Fraction and Α-Tocopherol in Glutamate-Induced Injury of Primary Astrocytes
por: Abedi, Zahra, et al.
Publicado: (2017)

Antioxidant, Anti-Inflammatory, and Metabolic Properties of Tocopherols and Tocotrienols: Clinical Implications for Vitamin E Supplementation in Diabetic Kidney Disease
por: Di Vincenzo, Angelo, et al.
Publicado: (2019)

Upregulation of LAMB1 via ERK/c-Jun Axis Promotes Gastric Cancer Growth and Motility
por: Lee, Hana, et al.
Publicado: (2021)

Associations of Serum Retinol, α-Tocopherol, and γ-Tocopherol with Biomarkers among Healthy Japanese Men
por: Zou, Yu, et al.
Publicado: (2014)

EGR1 upregulation following Venezuelan equine encephalitis virus infection is regulated by ERK and PERK pathways contributing to cell death
por: Dahal, Bibha, et al.
Publicado: (2020)

Comparing the effects of vitamin E tocotrienol-rich fraction supplementation and α-tocopherol supplementation on gene expression in healthy older adults
por: Ghani, Siti Madiani Abdul, et al.
Publicado: (2019)

Effect of palm-based tocotrienols and tocopherol mixture supplementation on platelet aggregation in subjects with metabolic syndrome: a randomised controlled trial
por: Gan, Yee-Lin, et al.
Publicado: (2017)

ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics
por: Levidou, Georgia, et al.
Publicado: (2012)

Genetic variation of γ-tocopherol methyltransferase gene contributes to elevated α-tocopherol content in soybean seeds
por: Dwiyanti, Maria S, et al.
Publicado: (2011)

Co-ordinated autophagy with resveratrol and γ-tocotrienol confers synergetic cardioprotection
por: Lekli, Istvan, et al.
Publicado: (2010)

Development of Orally Administered γ-Tocotrienol (GT3) Nanoemulsion for Radioprotection
por: Ledet, Grace A., et al.
Publicado: (2016)

Nicotine-induced cessation of embryonic development is reversed by γ-tocotrienol in mice
por: Kamsani, Yuhaniza Shafinie, et al.
Publicado: (2013)

γ-tocotrienol regulates gastric cancer by targeting notch signaling pathway
por: Xie, Ling, et al.
Publicado: (2023)

Engineering of a functional γ-tocopherol transfer protein
por: Aeschimann, Walter, et al.
Publicado: (2020)

A NANOG‐pERK reciprocal regulatory circuit regulates Nanog autoregulation and ERK signaling dynamics
por: Kale, Hanuman T, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_h49qap4o5qk6ie7pa3qdulgrst