Effect of CRISPR/Cas9-Mediated PD-1-Disrupted Primary Human Third-Generation CAR-T Cells Targeting EGFRvIII on In Vitro Human Glioblastoma Cell Growth

Glioblastoma (GBM), which is the most common malignant brain tumor, is resistant to standard treatments. Immunotherapy might be a promising alternative for the treatment of this cancer. Chimeric antigen receptor (CAR) is an artificially modified fusion protein that can be engineered to direct the sp...

Descripción completa

Detalles Bibliográficos
Autores principales: Nakazawa, Tsutomu, Natsume, Atsushi, Nishimura, Fumihiko, Morimoto, Takayuki, Matsuda, Ryosuke, Nakamura, Mitsutoshi, Yamada, Shuichi, Nakagawa, Ichiro, Motoyama, Yasushi, Park, Young-Soo, Tsujimura, Takahiro, Wakabayashi, Toshihiko, Nakase, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227242/
https://www.ncbi.nlm.nih.gov/pubmed/32316275
http://dx.doi.org/10.3390/cells9040998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227242/
https://www.ncbi.nlm.nih.gov/pubmed/32316275
http://dx.doi.org/10.3390/cells9040998

Ejemplares similares