The Curcumin Derivative, H10, Suppresses Hormone-Dependent Prostate Cancer by Inhibiting 17β-Hydroxysteroid Dehydrogenase Type 3

The 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) enzyme is a potential therapeutic target for hormone-dependent prostate cancer, as it is the key enzyme in the last step of testosterone (T) biosynthesis. A curcumin analog, H10, was optimized for inhibiting T production in LC540 cells that stab...

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Detalles Bibliográficos
Autores principales: Cheng, Yating, Yang, Yan, Wu, Yinan, Wang, Wencheng, Xiao, Lichun, Zhang, Yifan, Tang, Jianzhong, Huang, Ya-Dong, Zhang, Shu, Xiang, Qi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227374/
https://www.ncbi.nlm.nih.gov/pubmed/32457626
http://dx.doi.org/10.3389/fphar.2020.00637

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227374/
https://www.ncbi.nlm.nih.gov/pubmed/32457626
http://dx.doi.org/10.3389/fphar.2020.00637

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