Cargando…

Hybrid Stem Cell States: Insights Into the Relationship Between Mammary Development and Breast Cancer Using Single-Cell Transcriptomics

Similarities between stem cells and cancer cells have implicated mammary stem cells in breast carcinogenesis. Recent evidence suggests that normal breast stem cells exist in multiple phenotypic states: epithelial, mesenchymal, and hybrid epithelial/mesenchymal (E/M). Hybrid E/M cells in particular h...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thong, Tasha, Wang, Yutong, Brooks, Michael D., Lee, Christopher T., Scott, Clayton, Balzano, Laura, Wicha, Max S., Colacino, Justin A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227401/ https://www.ncbi.nlm.nih.gov/pubmed/32457901 http://dx.doi.org/10.3389/fcell.2020.00288

Ejemplares similares

Programmed Cell Death Ligand 1 Is Enriched in Mammary Stem Cells and Promotes Mammary Development and Regeneration
por: Wang, Ruirui, et al.
Publicado: (2021)

Embryonic Programs in Cancer and Metastasis—Insights From the Mammary Gland
por: Lee, May Yin
Publicado: (2022)

Expression of vimentin alters cell mechanics, cell-cell adhesion, and gene expression profiles suggesting the induction of a hybrid EMT in human mammary epithelial cells
por: Sivagurunathan, Suganya, et al.
Publicado: (2022)

Parabolic relationship between SMAD3 expression level and the reprogramming efficiency of goat induced mammary epithelial cells
por: Wu, Yulian, et al.
Publicado: (2022)

Single-Cell Transcriptomics Identifies Heterogeneity of Mouse Mammary Gland Fibroblasts With Distinct Functions, Estrogen Responses, Differentiation Processes, and Crosstalks With Epithelium
por: Yoshitake, Ryohei, et al.
Publicado: (2022)

Harshening stem cell research and precision medicine: The states of human pluripotent cells stem cell repository diversity, and racial and sex differences in transcriptomes
por: Nguyen, Thong Ba, et al.
Publicado: (2023)

Dissecting the molecular trajectory of fibroblast reprogramming to chemically induced mammary epithelial cells
por: Qin, Liangshan, et al.
Publicado: (2023)

Effects of Triiodothyronine on Human Osteoblast-Like Cells: Novel Insights From a Global Transcriptome Analysis
por: Rodrigues, Bruna Moretto, et al.
Publicado: (2022)

The Adipose Microenvironment Dysregulates the Mammary Myoepithelial Cells and Could Participate to the Progression of Breast Cancer
por: Delort, Laetitia, et al.
Publicado: (2021)

Transcriptome Analysis Reveals the Potential Role of Long Non-coding RNAs in Mammary Gland of Yak During Lactation and Dry Period
por: Wu, Xiaoyun, et al.
Publicado: (2020)

Notch3 Knockout Suppresses Mouse Mammary Gland Development and Inhibits the Proliferation of 4T1 Murine Mammary Carcinoma Cells via CCL2/CCR4 Axis
por: Xiong, Wei, et al.
Publicado: (2020)

Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells
por: Lee, Jonathan K., et al.
Publicado: (2015)

Nutritional Regulation of Mammary Tumor Microenvironment
por: Thakkar, Nikita, et al.
Publicado: (2022)

“In medio stat virtus”: Insights into hybrid E/M phenotype attitudes
por: Canciello, Angelo, et al.
Publicado: (2022)

Hormone-Responsive BMP Signaling Expands Myoepithelial Cell Lineages and Prevents Alveolar Precocity in Mammary Gland
por: Shao, Chunlei, et al.
Publicado: (2021)

Primary Mammary Organoid Model of Lactation and Involution
por: Sumbal, Jakub, et al.
Publicado: (2020)

Tumor Hybrid Cells: Nature and Biological Significance
por: Tretyakova, Maria S., et al.
Publicado: (2022)

EGF-Induced miR-223 Modulates Goat Mammary Epithelial Cell Apoptosis and Inflammation via ISG15
por: Zhang, Yue, et al.
Publicado: (2021)

Low-Level Mouse DNA in Conditioned Medium Generates False Positive Cross-Species Contamination Results in Human Organoid Cultures
por: Bohm, Margaret S., et al.
Publicado: (2020)

Transcriptional Repression of MFG-E8 Causes Disturbance in the Homeostasis of Cell Cycle Through DOCK/ZP4/STAT Signaling in Buffalo Mammary Epithelial Cells
por: Verma, Arvind K., et al.
Publicado: (2021)

Editorial: Perspectives in Mammary Gland Development and Breast Cancer Research
por: Vafaizadeh, Vida, et al.
Publicado: (2020)

Developmental Stage-Specific Distribution of Macrophages in Mouse Mammary Gland
por: Stewart, Teneale A., et al.
Publicado: (2019)

Transcriptome Profiling of the Ovarian Cells at the Single-Cell Resolution in Adult Asian Seabass
por: Liu, Xiaoli, et al.
Publicado: (2021)

Curcumin-Induced Global Profiling of Transcriptomes in Small Cell Lung Cancer Cells
por: Mo, Fei, et al.
Publicado: (2021)

Single-Cell Transcriptome Analysis Reveals Mesenchymal Stem Cells in Cavernous Hemangioma
por: Ji, Fulong, et al.
Publicado: (2022)

Single-cell transcriptome profiling reveals enriched memory T-cell subpopulations in hypertension
por: Wang, Xiaoqi, et al.
Publicado: (2023)

Cross-Species Analysis of Single-Cell Transcriptomic Data
por: Shafer, Maxwell E. R.
Publicado: (2019)

Mouse Oocytes, A Complex Single Cell Transcriptome
por: Wu, Di
Publicado: (2022)

Cell Cycle Commitment and the Origins of Cell Cycle Variability
por: Brooks, Robert F.
Publicado: (2021)

Mating to Intact, but Not Vasectomized, Males Elicits Changes in the Endometrial Transcriptome: Insights From the Bovine Model
por: Recuero, Sandra, et al.
Publicado: (2020)

Baicalin Promotes Mammary Gland Development via Steroid-Like Activities
por: Chen, Weizhen, et al.
Publicado: (2021)

Calpains, the proteases of two faces controlling the epithelial homeostasis in mammary gland
por: García-Trevijano, Elena R., et al.
Publicado: (2023)

Perilipin-2 promotes lipid droplet-plasma membrane interactions that facilitate apocrine lipid secretion in secretory epithelial cells of the mouse mammary gland
por: Monks, Jenifer, et al.
Publicado: (2022)

Single-cell transcriptomics reveals male germ cells and Sertoli cells developmental patterns in dairy goats
por: Ren, Fa, et al.
Publicado: (2022)

Corrigendum: Transcriptome Profiling of the Ovarian Cells at the Single-Cell Resolution in Adult Asian Seabass
por: Liu, Xiaoli, et al.
Publicado: (2021)

Single-Cell Transcriptomics of Proliferative Phase Endometrium: Systems Analysis of Cell–Cell Communication Network Using CellChat
por: Fang, Zishui, et al.
Publicado: (2022)

Transcriptomic Analysis Provides Insights to Reveal the bmp6 Function Related to the Development of Intermuscular Bones in Zebrafish
por: Xu, Huan, et al.
Publicado: (2022)

Transcriptomic Profiling of Zebrafish Hair Cells Using RiboTag
por: Matern, Maggie S., et al.
Publicado: (2018)

Fluorescence In situ Hybridization: Cell-Based Genetic Diagnostic and Research Applications
por: Cui, Chenghua, et al.
Publicado: (2016)

New insights into fibrotic signaling in renal cell carcinoma
por: Chen, Jiao-Yi, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_dgpqkcboh24lqgluajmmctvp4g