CRISPR-mediated ablation of overexpressed EGFR in combination with sunitinib significantly suppresses renal cell carcinoma proliferation

Receptor tyrosine kinases, such as VEGFR, PDGFR and EGFR, play important roles in renal cancer. In this study, we investigated EGFR knockout as a therapeutic approach in renal cell carcinoma (RCC). We showed that a renal cell carcinoma cell line (RC21) has higher expression of EGFR as compared to ot...

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Detalles Bibliográficos
Autores principales: Liu, Bin, Diaz Arguello, Olivia Adaly, Chen, Deng, Chen, Siwei, Saber, Ali, Haisma, Hidde J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228069/
https://www.ncbi.nlm.nih.gov/pubmed/32413049
http://dx.doi.org/10.1371/journal.pone.0232985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228069/
https://www.ncbi.nlm.nih.gov/pubmed/32413049
http://dx.doi.org/10.1371/journal.pone.0232985

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