Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1

The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (broad kinase inhibitor) and N-ethylmalemide (...

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Detalles Bibliográficos
Autores principales: Zhang, Jinwei, Cordshagen, Antje, Medina, Igor, Nothwang, Hans Gerd, Wisniewski, Jacek R., Winklhofer, Michael, Hartmann, Anna-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228128/
https://www.ncbi.nlm.nih.gov/pubmed/32413057
http://dx.doi.org/10.1371/journal.pone.0232967

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228128/
https://www.ncbi.nlm.nih.gov/pubmed/32413057
http://dx.doi.org/10.1371/journal.pone.0232967

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