Cargando…

Staurosporine and NEM mainly impair WNK-SPAK/OSR1 mediated phosphorylation of KCC2 and NKCC1

The pivotal role of KCC2 and NKCC1 in development and maintenance of fast inhibitory neurotransmission and their implication in severe human diseases arouse interest in posttranscriptional regulatory mechanisms such as (de)phosphorylation. Staurosporine (broad kinase inhibitor) and N-ethylmalemide (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Jinwei, Cordshagen, Antje, Medina, Igor, Nothwang, Hans Gerd, Wisniewski, Jacek R., Winklhofer, Michael, Hartmann, Anna-Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228128/ https://www.ncbi.nlm.nih.gov/pubmed/32413057 http://dx.doi.org/10.1371/journal.pone.0232967

Ejemplares similares

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation
por: Thastrup, Jacob O., et al.
Publicado: (2011)

Targeting the WNK-SPAK/OSR1 Pathway and Cation-Chloride Cotransporters for the Therapy of Stroke
por: Josiah, Sunday Solomon, et al.
Publicado: (2021)

Melatonin modulates nitric oxide-regulated WNK-SPAK/OSR1-NKCC1 signaling in dorsal raphe nucleus of rats
por: Yang, Hye Jin, et al.
Publicado: (2021)

The WNK-SPAK/OSR1 Kinases and the Cation-Chloride Cotransporters as Therapeutic Targets for Neurological Diseases
por: Huang, Huachen, et al.
Publicado: (2019)

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K(+)–Cl(−) co-transporters
por: delos Heros, Paola, et al.
Publicado: (2014)

NKCC1 and KCC2: Structural insights into phospho-regulation
por: Hartmann, Anna-Maria, et al.
Publicado: (2022)

Physiological Processes Modulated by the Chloride-Sensitive WNK-SPAK/OSR1 Kinase Signaling Pathway and the Cation-Coupled Chloride Cotransporters
por: Murillo-de-Ozores, Adrián Rafael, et al.
Publicado: (2020)

Ca(2+) is a Regulator of the WNK/OSR1/NKCC Pathway in a Human Salivary Gland Cell Line
por: Park, Soonhong, et al.
Publicado: (2015)

OSR1 and SPAK cooperatively modulate Sertoli cell support of mouse spermatogenesis
por: Liu, Yung-Liang, et al.
Publicado: (2016)

Consequences of SPAK inactivation on Hyperkalemic Hypertension caused by WNK1 mutations: evidence for differential roles of WNK1 and WNK4
por: Rafael, Chloé, et al.
Publicado: (2018)

Role of the WNK-activated SPAK kinase in regulating blood pressure
por: Rafiqi, Fatema H, et al.
Publicado: (2010)

SPAK Deficiency Corrects Pseudohypoaldosteronism II Caused by WNK4 Mutation
por: Chu, Pei-Yi, et al.
Publicado: (2013)

Role of SPAK–NKCC1 signaling cascade in the choroid plexus blood–CSF barrier damage after stroke
por: Wang, Jun, et al.
Publicado: (2022)

Role of NKCC1 and KCC2 in Epilepsy: From Expression to Function
por: Liu, Ru, et al.
Publicado: (2020)

WNK1/HSN2 isoform and the regulation of KCC2 activity
por: Bercier, Valérie
Publicado: (2013)

Opposite temperature effect on transport activity of KCC2/KCC4 and N(K)CCs in HEK-293 cells
por: Hartmann, Anna-Maria, et al.
Publicado: (2011)

Structural changes in the extracellular loop 2 of the murine KCC2 potassium chloride cotransporter modulate ion transport
por: Hartmann, Anna-Maria, et al.
Publicado: (2021)

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2
por: Zhang, Sensen, et al.
Publicado: (2021)

Expression of the kidney anion exchanger 1 affects WNK4 and SPAK phosphorylation and results in claudin-4 phosphorylation
por: Lashhab, Rawad, et al.
Publicado: (2023)

The effect of repeated stress on KCC2 and NKCC1 immunoreactivity in the hippocampus of female mice
por: Tsukahara, Takao, et al.
Publicado: (2016)

The role of KCC2 and NKCC1 in spinal cord injury: From physiology to pathology
por: Talifu, Zuliyaer, et al.
Publicado: (2022)

WNK1-OSR1 kinase-mediated phospho-activation of Na(+)-K(+)-2Cl(-) cotransporter facilitates glioma migration
por: Zhu, Wen, et al.
Publicado: (2014)

WNK1–OSR1 Signaling Regulates Angiogenesis-Mediated Metastasis towards Developing a Combinatorial Anti-Cancer Strategy
por: Hou, Chia-Ying, et al.
Publicado: (2022)

KCC2 expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses
por: Frederikse, Peter H., et al.
Publicado: (2015)

Role of NKCC1 and KCC2 during hypoxia-induced neuronal swelling in the neonatal neocortex
por: Takezawa, Yusuke, et al.
Publicado: (2023)

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
por: Lam, Patricia, et al.
Publicado: (2023)

Aldosterone does not require angiotensin II to activate NCC through a WNK4–SPAK–dependent pathway
por: van der Lubbe, Nils, et al.
Publicado: (2012)

Lateral Diffusion of NKCC1 Contributes to Chloride Homeostasis in Neurons and Is Rapidly Regulated by the WNK Signaling Pathway
por: Côme, Etienne, et al.
Publicado: (2023)

Layer-specific changes of KCC2 and NKCC1 in the mouse dentate gyrus after entorhinal denervation
por: Del Turco, Domenico, et al.
Publicado: (2023)

NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons
por: Pol, Erwan, et al.
Publicado: (2023)

GABA(A) receptor dependent synaptic inhibition rapidly tunes KCC2 activity via the Cl(−)-sensitive WNK1 kinase
por: Heubl, Martin, et al.
Publicado: (2017)

WNK1/HSN2 mediates neurite outgrowth and differentiation via a OSR1/GSK3β-LHX8 pathway
por: Shimizu, Masahiro, et al.
Publicado: (2022)

Decreased Immunoreactivities and Functions of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Circling Mice
por: Pradhan, Jonu, et al.
Publicado: (2011)

Decreased Immunoreactivities of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Kanamycin-treated Rats
por: Suh, Myung-Whan, et al.
Publicado: (2012)

Changes in expression of the chloride homeostasis-regulating genes, KCC2 and NKCC1, in the blood of cirrhotic patients with hepatic encephalopathy
por: LI, JUN-JIE, et al.
Publicado: (2012)

Ketogenic Diet Provided During Three Months Increases KCC2 Expression but Not NKCC1 in the Rat Dentate Gyrus
por: Granados-Rojas, Leticia, et al.
Publicado: (2020)

Chronic Metabolic Acidosis Activates Renal Tubular Sodium Chloride Cotransporter through Angiotension II-dependent WNK4-SPAK Phosphorylation Pathway
por: Fang, Yu-Wei, et al.
Publicado: (2016)

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo
por: Oi, Katsuyuki, et al.
Publicado: (2011)

THE WNK4/SPAK PATHWAY STIMULATES ALVEOLAR FLUID CLEARANCE BY UPREGULATION OF EPITHELIAL SODIUM CHANNEL IN MICE WITH LIPOPOLYSACCHARIDE-INDUCED ACUTE RESPIRATORY DISTRESS SYNDROME
por: Deng, Wang, et al.
Publicado: (2022)

KCC2 regulates actin dynamics in dendritic spines via interaction with β-PIX
por: Llano, Olaya, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_g1greg0cslvsd8c9dq60ghtvrn