Cargando…

Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice

BACKGROUND: Polychlorinated biphenyls (PCBs) are environmental toxicants; PCB exposure has been associated with adverse effects on wildlife and humans. However, the mechanisms underlying these adverse effects are not fully understood. The steroid and xenobiotic receptor [SXR; also known as the pregn...

Descripción completa

Detalles Bibliográficos
Autores principales:	Egusquiza, Riann Jenay, Ambrosio, Maria Elena, Wang, Shuyi Gin, Kay, Kaelen Marie, Zhang, Chunyun, Lehmler, Hans-Joachim, Blumberg, Bruce
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Environmental Health Perspectives 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228131/ https://www.ncbi.nlm.nih.gov/pubmed/32352317 http://dx.doi.org/10.1289/EHP6262

Ejemplares similares

Erratum: “Evaluating the Role of the Steroid and Xenobiotic Receptor (SXR/PXR) in PCB-153 Metabolism and Protection against Associated Adverse Effects during Perinatal and Chronic Exposure in Mice”
por: Egusquiza, Riann Jenay, et al.
Publicado: (2020)

The steroid and xenobiotic receptor (SXR), beyond xenobiotic metabolism
por: Zhou, Changcheng, et al.
Publicado: (2009)

Highly chlorinated PCBs inhibit the human xenobiotic response mediated by the steroid and xenobiotic receptor (SXR).
por: Tabb, Michelle M, et al.
Publicado: (2004)

Activation of the steroid and xenobiotic receptor, SXR, induces apoptosis in breast cancer cells
por: Verma, Suman, et al.
Publicado: (2009)

Environmental Obesogens and Their Impact on Susceptibility to Obesity: New Mechanisms and Chemicals
por: Egusquiza, Riann Jenay, et al.
Publicado: (2020)

Irinotecan induces steroid and xenobiotic receptor (SXR) signaling to detoxification pathway in colon cancer cells
por: Basseville, Agnes, et al.
Publicado: (2011)

Activation of Steroid and Xenobiotic Receptor (SXR, NR1I2) and Its Orthologs in Laboratory, Toxicologic, and Genome Model Species
por: Milnes, Matthew R., et al.
Publicado: (2008)

Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants
por: Aqil, Farrukh, et al.
Publicado: (2014)

A brief history of the discovery of PXR and CAR as xenobiotic receptors
por: Yan, Jiong, et al.
Publicado: (2016)

Pulse energy measurement at the SXR instrument
por: Moeller, Stefan, et al.
Publicado: (2015)

In Vitro Exposure of Porcine Ovarian Follicular Cells to PCB 153 Alters Steroid Secretion But Not Their Viability—Preliminary Study
por: Gregoraszczuk, Ewa L., et al.
Publicado: (2002)

Subchronic Exposure to TCDD, PeCDF, PCB126, and PCB153: Effect on Hepatic Gene Expression
por: Vezina, Chad M., et al.
Publicado: (2004)

PCB-153 Shows Different Dynamics of Mobilisation from Differentiated Rat Adipocytes during Lipolysis in Comparison with PCB-28 and PCB-118
por: Louis, Caroline, et al.
Publicado: (2014)

In Vitro Cocktail Effects of PCB-DL (PCB118) and Bulky PCB (PCB153) with BaP on Adipogenesis and on Expression of Genes Involved in the Establishment of a Pro-Inflammatory State
por: May, Phealay, et al.
Publicado: (2018)

In vivo and in vitro exposure to PCB 153 reduces long-term potentiation.
por: Hussain, R J, et al.
Publicado: (2000)

A Measure for Mothers: Model Predicts Lactational Transfer of PCB-153
por: Mead, M. Nathaniel
Publicado: (2008)

Ortho-substituted PCB 153: effects in CHO-K1 cells
por: Miletić, Marina, et al.
Publicado: (2021)

Postnatal exposure to PCB 153 and PCB 180, but not to PCB 52, produces changes in activity level and stimulus control in outbred male Wistar Kyoto rats
por: Johansen, Espen Borgå, et al.
Publicado: (2011)

Toxicogenomic analysis of exposure to TCDD, PCB126 and PCB153: identification of genomic biomarkers of exposure to AhR ligands
por: Ovando, Bladimir J, et al.
Publicado: (2010)

PCB153-Induced Overexpression of ID3 Contributes to the Development of Microvascular Lesions
por: Das, Jayanta K., et al.
Publicado: (2014)

Epidermal Overexpression of Xenobiotic Receptor PXR Impairs the Epidermal Barrier and Triggers Th2 Immune Response
por: Elentner, Andreas, et al.
Publicado: (2017)

Modulation of Xenobiotic Receptors by Steroids
por: Banerjee, Monimoy, et al.
Publicado: (2013)

Prenatal PCB-153 Exposure and Decreased Birth Weight: The Role of Gestational Weight Gain
por: Govarts, Eva, et al.
Publicado: (2014)

Prenatal PCB-153 Exposure and Decreased Birth Weight: Verner et al. Respond
por: Verner, Marc-André, et al.
Publicado: (2014)

TLR4 Signaling Is Involved in Brain Vascular Toxicity of PCB153 Bound to Nanoparticles
por: Zhang, Bei, et al.
Publicado: (2013)

Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?
por: Verner, Marc-André, et al.
Publicado: (2013)

NADPH Oxidase Inhibitor Apocynin Attenuates PCB153-Induced Thyroid Injury in Rats
por: Abliz, Ablikim, et al.
Publicado: (2016)

The Transcriptional Effects of PCB118 and PCB153 on the Liver, Adipose Tissue, Muscle and Colon of Mice: Highlighting of Glut4 and Lipin1 as Main Target Genes for PCB Induced Metabolic Disorders
por: Mesnier, Aurélia, et al.
Publicado: (2015)

Erratum: “Is the Relationship between Prenatal Exposure to PCB-153 and Decreased Birth Weight Attributable to Pharmacokinetics?”
Publicado: (2014)

Correction: TLR4 Signaling Is Involved in Brain Vascular Toxicity of PCB153 Bound to Nanoparticles
por: Zhang, Bei, et al.
Publicado: (2014)

Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice
por: Little, Mallory, et al.
Publicado: (2022)

Predicted Versus Observed Activity of PCB Mixtures Toward the Ryanodine Receptor
por: Griffin, Justin A., et al.
Publicado: (2023)

First exploitation results of recently developed SXR GEM-based diagnostics at the WEST project
por: Chernyshova, Maryna, et al.
Publicado: (2020)

Population Physiologically Based Pharmacokinetic Modeling for the Human Lactational Transfer of PCB-153 with Consideration of Worldwide Human Biomonitoring Results
por: Redding, Laurel E., et al.
Publicado: (2008)

Behavioral changes following PCB 153 exposure in the Spontaneously Hypertensive rat – an animal model of Attention-Deficit/Hyperactivity disorder
por: Johansen, Espen Borgå, et al.
Publicado: (2014)

A Birth Cohort Study of Maternal and Infant Serum PCB-153 and DDE Concentrations and Responses to Infant Tuberculosis Vaccination
por: Jusko, Todd A., et al.
Publicado: (2015)

Updating “Dataset of transcriptomic changes that occur in human preadipocytes over a 3-day course of exposure to 3,3′,4,4′,5-Pentachlorobiphenyl (PCB126)” with additional data on exposure to 2,2′,5,5′-tetrachlorobiphenyl (PCB52) or its 4-hydroxy metabolite (4-OH-PCB52)
por: Gourronc, Francoise A., et al.
Publicado: (2023)

Steroid and Xenobiotic Receptor Signalling in Apoptosis and Autophagy of the Nervous System
por: Wnuk, Agnieszka, et al.
Publicado: (2017)

2,2′,3,5′,6-Pentachlorobiphenyl (PCB 95) Is Atropselectively Metabolized to para-Hydroxylated Metabolites by Human Liver Microsomes
por: Uwimana, Eric, et al.
Publicado: (2016)

Liver transcriptome analysis of Atlantic cod (Gadus morhua) exposed to PCB 153 indicates effects on cell cycle regulation and lipid metabolism
por: Yadetie, Fekadu, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_020777b4pmt00ors9mm10gjmh9