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Targeting pulmonary tumor microenvironment with CXCR4-inhibiting nanocomplex to enhance anti–PD-L1 immunotherapy

Anti–programmed cell death 1 ligand 1 (PD-L1) therapy is extraordinarily effective in select patients with cancer. However, insufficient lymphocytic infiltration, weak T cell–induced inflammation, and immunosuppressive cell accumulation in the tumor microenvironment (TME) may greatly diminish the ef...

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Detalles Bibliográficos
Autores principales: Li, Zhaoting, Wang, Yixin, Shen, Yuexin, Qian, Chenggen, Oupicky, David, Sun, Minjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228744/
https://www.ncbi.nlm.nih.gov/pubmed/32440550
http://dx.doi.org/10.1126/sciadv.aaz9240