Intravascular flow stimulates PKD2 (polycystin-2) channels in endothelial cells to reduce blood pressure

PKD2 (polycystin-2, TRPP1), a TRP polycystin channel, is expressed in endothelial cells (ECs), but its physiological functions in this cell type are unclear. Here, we generated inducible, EC-specific Pkd2 knockout mice to examine vascular functions of PKD2. Data show that a broad range of intravascu...

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Detalles Bibliográficos
Autores principales: MacKay, Charles E, Leo, M Dennis, Fernández-Peña, Carlos, Hasan, Raquibul, Yin, Wen, Mata-Daboin, Alejandro, Bulley, Simon, Gammons, Jesse, Mancarella, Salvatore, Jaggar, Jonathan H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228764/
https://www.ncbi.nlm.nih.gov/pubmed/32364494
http://dx.doi.org/10.7554/eLife.56655

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7228764/
https://www.ncbi.nlm.nih.gov/pubmed/32364494
http://dx.doi.org/10.7554/eLife.56655

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