Synergistic lipid compositions for albumin receptor mediated delivery of mRNA to the liver

Lipid-like nanoparticles (LNPs) have potential as non-viral delivery systems for mRNA therapies. However, repeated administrations of LNPs may lead to accumulation of delivery materials and associated toxicity. To address this challenge, we have developed biodegradable lipids which improve LNPs clea...

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Detalles Bibliográficos
Autores principales: Miao, Lei, Lin, Jiaqi, Huang, Yuxuan, Li, Linxian, Delcassian, Derfogail, Ge, Yifan, Shi, Yunhua, Anderson, Daniel G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229004/
https://www.ncbi.nlm.nih.gov/pubmed/32415122
http://dx.doi.org/10.1038/s41467-020-16248-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229004/
https://www.ncbi.nlm.nih.gov/pubmed/32415122
http://dx.doi.org/10.1038/s41467-020-16248-y

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