Serelaxin activates eNOS, suppresses inflammation, attenuates developmental delay and improves cognitive functions of neonatal rats after germinal matrix hemorrhage

Germinal matrix hemorrhage (GMH) is a detrimental form of neonatal CNS injury. Following GMH-mediated eNOS inhibition, inflammation arises, contributing to GMH-induced brain injury. We investigated the beneficial effects of Serelaxin, a clinical tested recombinant Relaxin-2 protein, on brain injury...

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Detalles Bibliográficos
Autores principales: Xu, Ming M., Seyler, L., Bäuerle, T., Kalinichenko, L. S., Müller, C. P., Huttner, H. B., Schwab, S., Manaenko, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229117/
https://www.ncbi.nlm.nih.gov/pubmed/32415164
http://dx.doi.org/10.1038/s41598-020-65144-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229117/
https://www.ncbi.nlm.nih.gov/pubmed/32415164
http://dx.doi.org/10.1038/s41598-020-65144-4

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