Atypical chemokine receptor ACKR2-V41A has decreased CCL2 binding, scavenging, and activation, supporting sustained inflammation and increased Alzheimer’s disease risk

A recent genome-wide association study (GWAS) of 59 cerebrospinal fluid (CSF) proteins with a connection to Alzheimer’s disease (AD) demonstrated an association between increased levels of chemokine ligand 2 (CCL2) with an atypical chemokine receptor chemokine-binding protein 2 variant V41A (ACKR2-V...

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Detalles Bibliográficos
Autores principales: Murcia, Josue D. Gonzalez, Weinert, Allen, Freitas, Claudia M. Tellez, Arens, Daniel K., Ferrel, Meganne N., Grose, Julianne H., Ridge, Perry G., Wilson, Eric, Kauwe, John S. K., Weber, K. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229167/
https://www.ncbi.nlm.nih.gov/pubmed/32415244
http://dx.doi.org/10.1038/s41598-020-64755-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229167/
https://www.ncbi.nlm.nih.gov/pubmed/32415244
http://dx.doi.org/10.1038/s41598-020-64755-1

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