Cargando…

The native ORAI channel trio underlies the diversity of Ca(2+) signaling events

The essential role of ORAI1 channels in receptor-evoked Ca(2+) signaling is well understood, yet little is known about the physiological activation of the ORAI channel trio natively expressed in all cells. The roles of ORAI2 and ORAI3 have remained obscure. We show that ORAI2 and ORAI3 channels play...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yoast, Ryan E., Emrich, Scott M., Zhang, Xuexin, Xin, Ping, Johnson, Martin T., Fike, Adam J., Walter, Vonn, Hempel, Nadine, Yule, David I., Sneyd, James, Gill, Donald L., Trebak, Mohamed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229178/ https://www.ncbi.nlm.nih.gov/pubmed/32415068 http://dx.doi.org/10.1038/s41467-020-16232-6

Ejemplares similares

Omnitemporal choreographies of all five STIM/Orai and IP(3)Rs underlie the complexity of mammalian Ca(2+) signaling
por: Emrich, Scott M., et al.
Publicado: (2021)

Orai3 and Orai1 mediate CRAC channel function and metabolic reprogramming in B cells
por: Emrich, Scott M, et al.
Publicado: (2023)

A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction
por: Zhang, Xuexin, et al.
Publicado: (2019)

Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis
por: Pathak, Trayambak, et al.
Publicado: (2020)

Correction: Dichotomous role of the human mitochondrial Na(+)/Ca2(+)/Li(+) exchanger NCLX in colorectal cancer growth and metastasis
por: Pathak, Trayambak, et al.
Publicado: (2023)

The Mitochondrial Ca(2+) uniporter is a central regulator of interorganellar Ca(2+) transfer and NFAT activation
por: Yoast, Ryan E., et al.
Publicado: (2021)

A protocol for detecting elemental calcium signals (Ca(2+) puffs) in mammalian cells using total internal reflection fluorescence microscopy
por: Arige, Vikas, et al.
Publicado: (2021)

The remote allosteric control of Orai channel gating
por: Zhou, Yandong, et al.
Publicado: (2019)

A multiple-oscillator mechanism underlies antigen-induced Ca(2+) oscillations in Jurkat T-cells
por: Benson, J. Cory, et al.
Publicado: (2023)

STIM1 is a core trigger of airway smooth muscle remodeling and hyperresponsiveness in asthma
por: Johnson, Martin T., et al.
Publicado: (2021)

Complex role of STIM1 in the activation of store-independent Orai1/3 channels
por: Zhang, Xuexin, et al.
Publicado: (2014)

Orai channel C-terminal peptides are key modulators of STlM-Orai coupling and calcium signal generation
por: Baraniak, James H., et al.
Publicado: (2021)

The STIM1-binding site nexus remotely controls Orai1 channel gating
por: Zhou, Yandong, et al.
Publicado: (2016)

The airway smooth muscle sodium/calcium exchanger NCLX is critical for airway remodeling and hyperresponsiveness in asthma
por: Johnson, Martin T., et al.
Publicado: (2022)

Orai channels: key players in Ca(2+) homeostasis
por: Sallinger, Matthias, et al.
Publicado: (2020)

Sphingomyelin, ORAI1 channels, and cellular Ca(2+) signaling
por: Hogan, Patrick G.
Publicado: (2015)

Structural Insights into Ca(2+) Permeation through Orai Channels
por: Li, Yang, et al.
Publicado: (2021)

SPLUNC1 is a negative regulator of the Orai1 Ca(2+) channel
por: Wu, Tongde, et al.
Publicado: (2022)

Cardiac‐Specific Deletion of Orai3 Leads to Severe Dilated Cardiomyopathy and Heart Failure in Mice
por: Gammons, Jesse, et al.
Publicado: (2021)

ORAI1 Ca(2+) Channel as a Therapeutic Target in Pathological Vascular Remodelling
por: Shawer, Heba, et al.
Publicado: (2021)

Orai3 mediates Orai channel remodelling to activate fibroblast in pulmonary fibrosis
por: Yu, Changhui, et al.
Publicado: (2022)

Orai1 calcium channels in the vasculature
por: Beech, David J
Publicado: (2012)

The Contribution of Orai(CRACM)1 and Orai(CRACM)2 Channels in Store-Operated Ca(2+) Entry and Mediator Release in Human Lung Mast Cells
por: Ashmole, Ian, et al.
Publicado: (2013)

Loss of STIM2 in colorectal cancer drives growth and metastasis through metabolic reprogramming and PERK-ATF4 endoplasmic reticulum stress pathway
por: Pathak, Trayambak, et al.
Publicado: (2023)

STIM1 dimers undergo unimolecular coupling to activate Orai1 channels
por: Zhou, Yandong, et al.
Publicado: (2015)

In this issue of Channels: Special issue on STIM and Orai
por: Romanin, Christoph
Publicado: (2013)

Toward a Model for Activation of Orai Channel
por: Dong, Hao, et al.
Publicado: (2019)

Constitutive recycling of the store-operated Ca(2+) channel Orai1 and its internalization during meiosis
por: Yu, Fang, et al.
Publicado: (2010)

AKAP79 Orchestrates a Cyclic AMP Signalosome Adjacent to Orai1 Ca(2+) Channels
por: Kar, Pulak, et al.
Publicado: (2021)

PKC-Mediated Orai1 Channel Phosphorylation Modulates Ca(2+) Signaling in HeLa Cells
por: Martínez-Martínez, Ericka, et al.
Publicado: (2022)

Orai1 is an Entotic Ca(2+) Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development
por: Lee, Ah Reum, et al.
Publicado: (2023)

Selective recruitment of different Ca(2+)-dependent transcription factors by STIM1-Orai1 channel clusters
por: Lin, Yu-Ping, et al.
Publicado: (2019)

Thiol dependent intramolecular locking of Orai1 channels
por: Alansary, Dalia, et al.
Publicado: (2016)

ORAI channels are critical for receptor-mediated endocytosis of albumin
por: Zeng, Bo, et al.
Publicado: (2017)

The exquisitely cooperative nature of Orai1 channel activation
por: Yeung, Priscilla See-Wai, et al.
Publicado: (2018)

Orai1 Boosts SK3 Channel Activation
por: Tiffner, Adéla, et al.
Publicado: (2021)

Regulation of neuropathic pain by microglial Orai1 channels
por: Tsujikawa, Shogo, et al.
Publicado: (2023)

Stim and Orai proteins in neuronal Ca(2+) signaling and excitability
por: Moccia, Francesco, et al.
Publicado: (2015)

Cell-wide mapping of Orai1 channel activity reveals functional heterogeneity in STIM1-Orai1 puncta
por: Dynes, Joseph L., et al.
Publicado: (2020)

The Orai1-AC8 Interplay: How Breast Cancer Cells Escape from Orai1 Channel Inactivation
por: Sánchez-Collado, José, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ttlrsemhch81s5tk0mumm8sip5