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High efficiency CHO cell display-based antibody maturation

Previously, we developed a CHO cell display-based antibody maturation procedure in which an antibody (or other protein) gene of interest was induced to mutate by activation-induced cytidine deaminase (AID) and then form a library by simply proliferating the CHO cells in culture. In this study, we fu...

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Detalles Bibliográficos
Autores principales: Luo, Ruiqi, Zhao, Yun, Fan, Yingjun, An, Lili, Jiang, Tao, Ma, Shaohua, Hang, Haiying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229201/
https://www.ncbi.nlm.nih.gov/pubmed/32415149
http://dx.doi.org/10.1038/s41598-020-65044-7