Suppressed expression of LDHB promotes age-related hearing loss via aerobic glycolysis

Age-dependent decrease of mitochondrial energy production and cellular redox imbalance play significant roles in age-related hearing loss (ARHL). Lactate dehydrogenase B (LDHB) is a key glycolytic enzyme that catalyzes the interconversion of pyruvate and lactate. LDH activity and isoenzyme patterns...

Descripción completa

Detalles Bibliográficos
Autores principales: Tian, Chunjie, Kim, Yeon Ju, Hali, Sai, Choo, Oak-Sung, Lee, Jin-Sol, Jung, Seo-Kyung, Choi, Youn-Uk, Park, Chan Bae, Choung, Yun-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229204/
https://www.ncbi.nlm.nih.gov/pubmed/32415082
http://dx.doi.org/10.1038/s41419-020-2577-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229204/
https://www.ncbi.nlm.nih.gov/pubmed/32415082
http://dx.doi.org/10.1038/s41419-020-2577-y

Ejemplares similares