Genotoxic potential of a novel PDE-4B inhibitor Apremilast by chromosomal aberration and micronucleus assay in mice

OBJECTIVE: Researchers have confirmed that chronic administration of drugs at high doses causes genotoxicity which serve as first step in development of cancers. Apremilast, a phosphodiesterase-4 inhibitor is Food and Drug Administration (FDA) approved drug for Psoriatic Arthritis. The present study...

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Detalles Bibliográficos
Autores principales: Afzal, Muhammad, Kazmi, Imran, Alharbi, Khalid Saad, Quazi, Anwarulabedin Mohsin, Nadeem, Muhammad Shahid, Alotaibi, Nasser Hadal, Ameeduzzafar, Alruwaili, Nabil K., Anwar, Firoz, Alenezi, Sattam Khulaif, Al-sanea, Mohammad M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229325/
https://www.ncbi.nlm.nih.gov/pubmed/32435143
http://dx.doi.org/10.1016/j.jsps.2020.03.014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229325/
https://www.ncbi.nlm.nih.gov/pubmed/32435143
http://dx.doi.org/10.1016/j.jsps.2020.03.014

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