Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial

BACKGROUND: Due to limited financial resources, poor access to basic oral care, and the high cost of restorative treatment, children of low-income nations have their general health, social well-being, and education opportunities affected by untreated dental caries. Arresting caries treatment (ACT) h...

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Autores principales: Nagireddy, Venugopal R, Reddy, Daneswari, Kondamadugu, Saigeeta, Puppala, Niharika, Mareddy, Ajayreddy, Chris, Annie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Jaypee Brothers Medical Publishers 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229382/
https://www.ncbi.nlm.nih.gov/pubmed/32440060
http://dx.doi.org/10.5005/jp-journals-10005-1703
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author Nagireddy, Venugopal R
Reddy, Daneswari
Kondamadugu, Saigeeta
Puppala, Niharika
Mareddy, Ajayreddy
Chris, Annie
author_facet Nagireddy, Venugopal R
Reddy, Daneswari
Kondamadugu, Saigeeta
Puppala, Niharika
Mareddy, Ajayreddy
Chris, Annie
author_sort Nagireddy, Venugopal R
collection PubMed
description BACKGROUND: Due to limited financial resources, poor access to basic oral care, and the high cost of restorative treatment, children of low-income nations have their general health, social well-being, and education opportunities affected by untreated dental caries. Arresting caries treatment (ACT) has been proposed to manage untreated dental caries in children of disadvantaged communities. AIMS AND OBJECTIVES: The purpose of the present controlled clinical trial is to investigate the effectiveness of a new anticaries agent, nanosilver fluoride (NSF), preventing and arresting caries in children. MATERIALS AND METHODS: A total of 100 deciduous molars both maxillary and mandibular are randomly selected from 60 children of 4–9 years of age group, which were randomly divided into NSF experimental group and saline control group. Teeth were clinically diagnosed and treated by one masked examiner and followed up at 7 days, 5 months and 12 months by another calibrated examiner who was blinded to the type of treatment. The criteria of the ICDAS II were followed to determine the activity of lesion and the diagnosis of caries. The Pearson's Chi-square test was used to compare the groups during different follow-up examinations. RESULTS: Seventy-eight percent of decayed teeth showed hard arrested dentine at 7 days; after 5-month analysis in the NSF group, 72.91% of the teeth showed arrested caries; and in the control group, only 34% of teeth showed arrest of caries. At 12-month analysis in the NSF group, 65.21% of teeth showed arrested cavities, and in the control group, 28.88% of teeth showed arrest of caries. CONCLUSION: The present study proves that NSF is an anticaries agent and presents a noninvasive option for caries arrest and treatment when applied directly to dentin caries lesions. HOW TO CITE THIS ARTICLE: Nagireddy VR, Reddy D, Kondamadugu S, et al. Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial. Int J Clin Pediatr Dent 2019;12(6):484–490.
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spelling pubmed-72293822020-05-21 Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial Nagireddy, Venugopal R Reddy, Daneswari Kondamadugu, Saigeeta Puppala, Niharika Mareddy, Ajayreddy Chris, Annie Int J Clin Pediatr Dent Original Article BACKGROUND: Due to limited financial resources, poor access to basic oral care, and the high cost of restorative treatment, children of low-income nations have their general health, social well-being, and education opportunities affected by untreated dental caries. Arresting caries treatment (ACT) has been proposed to manage untreated dental caries in children of disadvantaged communities. AIMS AND OBJECTIVES: The purpose of the present controlled clinical trial is to investigate the effectiveness of a new anticaries agent, nanosilver fluoride (NSF), preventing and arresting caries in children. MATERIALS AND METHODS: A total of 100 deciduous molars both maxillary and mandibular are randomly selected from 60 children of 4–9 years of age group, which were randomly divided into NSF experimental group and saline control group. Teeth were clinically diagnosed and treated by one masked examiner and followed up at 7 days, 5 months and 12 months by another calibrated examiner who was blinded to the type of treatment. The criteria of the ICDAS II were followed to determine the activity of lesion and the diagnosis of caries. The Pearson's Chi-square test was used to compare the groups during different follow-up examinations. RESULTS: Seventy-eight percent of decayed teeth showed hard arrested dentine at 7 days; after 5-month analysis in the NSF group, 72.91% of the teeth showed arrested caries; and in the control group, only 34% of teeth showed arrest of caries. At 12-month analysis in the NSF group, 65.21% of teeth showed arrested cavities, and in the control group, 28.88% of teeth showed arrest of caries. CONCLUSION: The present study proves that NSF is an anticaries agent and presents a noninvasive option for caries arrest and treatment when applied directly to dentin caries lesions. HOW TO CITE THIS ARTICLE: Nagireddy VR, Reddy D, Kondamadugu S, et al. Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial. Int J Clin Pediatr Dent 2019;12(6):484–490. Jaypee Brothers Medical Publishers 2019 /pmc/articles/PMC7229382/ /pubmed/32440060 http://dx.doi.org/10.5005/jp-journals-10005-1703 Text en Copyright © 2019; Jaypee Brothers Medical Publishers (P) Ltd. © The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted use, distribution, and non-commercial reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Article
Nagireddy, Venugopal R
Reddy, Daneswari
Kondamadugu, Saigeeta
Puppala, Niharika
Mareddy, Ajayreddy
Chris, Annie
Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial
title Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial
title_full Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial
title_fullStr Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial
title_full_unstemmed Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial
title_short Nanosilver Fluoride—A Paradigm Shift for Arrest in Dental Caries in Primary Teeth of Schoolchildren: A Randomized Controlled Clinical Trial
title_sort nanosilver fluoride—a paradigm shift for arrest in dental caries in primary teeth of schoolchildren: a randomized controlled clinical trial
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229382/
https://www.ncbi.nlm.nih.gov/pubmed/32440060
http://dx.doi.org/10.5005/jp-journals-10005-1703
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