Cargando…

Hepatic expression of lipopolysaccharide-binding protein (Lbp) is induced by the gut microbiota through Myd88 and impairs glucose tolerance in mice independent of obesity

OBJECTIVE: Gut-derived inflammatory factors can impair glucose homeostasis, but the underlying mechanisms are not fully understood. In this study, we investigated how hepatic gene expression is regulated by gut colonization status through myeloid differentiation primary response 88 (MYD88) and how o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Molinaro, Antonio, Koh, Ara, Wu, Hao, Schoeler, Marc, Faggi, Maria Ilaria, Carreras, Alba, Hallén, Anna, Bäckhed, Fredrik, Caesar, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229497/ https://www.ncbi.nlm.nih.gov/pubmed/32305515 http://dx.doi.org/10.1016/j.molmet.2020.100997

Ejemplares similares

Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice
por: Caesar, Robert, et al.
Publicado: (2012)

Liver-specific RORα deletion does not affect the metabolic susceptibility to western style diet feeding
por: Molinaro, Antonio, et al.
Publicado: (2019)

Lipopolysaccharide-induced NF-κB nuclear translocation is primarily dependent on MyD88, but TNFα expression requires TRIF and MyD88
por: Sakai, Jiro, et al.
Publicado: (2017)

MyD88 deficiency aggravates the severity of acute pancreatitis by promoting MyD88-independent TRIF pathway-mediated necrosis
por: Yang, Du-Jiang, et al.
Publicado: (2022)

Mucus clearance, MyD88-dependent and MyD88-independent immunity modulate lung susceptibility to spontaneous bacterial infection and inflammation
por: Livraghi-Butrico, Alessandra, et al.
Publicado: (2012)

Alternative activation of macrophages by filarial nematodes is MyD88-independent
por: Mylonas, Katie J., et al.
Publicado: (2013)

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
por: Everard, Amandine, et al.
Publicado: (2014)

Host-Microbiota Interaction is MyD88-Independent in the Intestinal Tract under Physiologic Condition
por: Moossavi, Shirin, et al.
Publicado: (2012)

miLBP: a robust and fast modality-independent 3D LBP for multimodal deformable registration
por: Jiang, Dongsheng, et al.
Publicado: (2016)

MyD88 But Not TRIF Is Essential for Osteoclastogenesis Induced by Lipopolysaccharide, Diacyl Lipopeptide, and IL-1α
por: Sato, Nobuaki, et al.
Publicado: (2004)

Analysis of gut microbial regulation of host gene expression along the length of the gut and regulation of gut microbial ecology through MyD88
por: Larsson, Erik, et al.
Publicado: (2011)

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism
por: Duparc, Thibaut, et al.
Publicado: (2017)

Host–microbiota interaction induces bi-phasic inflammation and glucose intolerance in mice
por: Molinaro, Antonio, et al.
Publicado: (2017)

SYK is activated by mutated MYD88 and drives pro-survival signaling in MYD88 driven B-cell lymphomas
por: Munshi, Manit, et al.
Publicado: (2020)

MyD88 and beyond: a perspective on MyD88-targeted therapeutic approach for modulation of host immunity
por: Saikh, Kamal U.
Publicado: (2021)

Schisandrin B Attenuates Diabetic Cardiomyopathy by Targeting MyD88 and Inhibiting MyD88‐Dependent Inflammation
por: Luo, Wu, et al.
Publicado: (2022)

BAFF and MyD88 signals promote a lupuslike disease independent of T cells
por: Groom, Joanna R., et al.
Publicado: (2007)

TLR4/MyD88 -mediated CCL2 production by lipopolysaccharide (endotoxin): Implications for metabolic inflammation
por: Akhter, Nadeem, et al.
Publicado: (2018)

Comparison of CRISPR and adenovirus-mediated Myd88 knockdown in RAW 264.7 cells and responses to lipopolysaccharide stimulation
por: Kolb, Alexander L., et al.
Publicado: (2021)

A MyD88 meddles with survival
por: Bashyam, Hema
Publicado: (2007)

Role of MyD88 in Adenovirus Keratitis
por: Zhou, Xiaohong, et al.
Publicado: (2016)

Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance
por: Wang, James Q., et al.
Publicado: (2014)

Protective role of MyD88-independent innate immune responses against prion infection
por: Ishibashi, Daisuke, et al.
Publicado: (2012)

Soyasaponins reduce inflammation by downregulating MyD88 expression and suppressing the recruitments of TLR4 and MyD88 into lipid rafts
por: Chen, Junbin, et al.
Publicado: (2020)

Determinants of Serum Concentrations of Lipopolysaccharide-Binding Protein (LBP) in the Adult Population: The Role of Obesity
por: Gonzalez-Quintela, Arturo, et al.
Publicado: (2013)

Lipopolysaccharide binding protein (L.B.P.) – an inflammatory marker of prognosis in the acute appendicitis
por: Brănescu, C, et al.
Publicado: (2012)

2′-Fluoro-Pyrimidine-Modified RNA Aptamers Specific for Lipopolysaccharide Binding Protein (LBP)
por: Aldag, Jasmin, et al.
Publicado: (2018)

A New LBP Variant: Corner Rhombus Shape LBP (CRSLBP)
por: Al Saidi, Ibtissam, et al.
Publicado: (2022)

Myd88 Is Required for an Antibody Response to Retroviral Infection
por: Browne, Edward P., et al.
Publicado: (2009)

MyD88 contribution to ocular surface homeostasis
por: Reins, Rose Y., et al.
Publicado: (2017)

Mechanism of MyD88S mediated signal termination
por: Pustelny, Katarzyna, et al.
Publicado: (2022)

A Novel Kindred with MyD88 Deficiency
por: Bucciol, Giorgia, et al.
Publicado: (2022)

Identification and Function of Myeloid Differentiation Factor 88 (MyD88) in Litopenaeus vannamei
por: Zhang, Shuang, et al.
Publicado: (2012)

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly
por: George, Julie, et al.
Publicado: (2011)

MyD88-Dependent Signaling Contributes to Host Defense against Ehrlichial Infection
por: Koh, Young-Sang, et al.
Publicado: (2010)

Microbial signals, MyD88, and lymphotoxin drive TNF-independent intestinal epithelial tissue damage
por: Rusu, Iulia, et al.
Publicado: (2022)

Lipopolysaccharide Induces Inflammatory Hyperalgesia Triggering a TLR4/MyD88-Dependent Cytokine Cascade in the Mice Paw
por: Calil, Igor L., et al.
Publicado: (2014)

Co-exposure to lipopolysaccharide and desert dust causes exacerbation of ovalbumin-induced allergic lung inflammation in mice via TLR4/MyD88-dependent and -independent pathways
por: Ren, Yahao, et al.
Publicado: (2019)

Myeloid Differentiation Factor 88 (MyD88)-Deficiency Increases Risk of Diabetes in Mice
por: Hosoi, Toru, et al.
Publicado: (2010)

Identification and characterization of lipopolysaccharide binding protein (LBP) as an estrogen receptor α specific serum biomarker
por: Chisamore, Michael J, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_dtpkro2oniccooo4qfe0o1q7pc