Quantitative analysis of amino acid metabolism in liver cancer links glutamate excretion to nucleotide synthesis

Many cancer cells consume glutamine at high rates; counterintuitively, they simultaneously excrete glutamate, the first intermediate in glutamine metabolism. Glutamine consumption has been linked to replenishment of tricarboxylic acid cycle (TCA) intermediates and synthesis of adenosine triphosphate...

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Detalles Bibliográficos
Autores principales: Nilsson, Avlant, Haanstra, Jurgen R., Engqvist, Martin, Gerding, Albert, Bakker, Barbara M., Klingmüller, Ursula, Teusink, Bas, Nielsen, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229649/
https://www.ncbi.nlm.nih.gov/pubmed/32341162
http://dx.doi.org/10.1073/pnas.1919250117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7229649/
https://www.ncbi.nlm.nih.gov/pubmed/32341162
http://dx.doi.org/10.1073/pnas.1919250117

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